2y5t

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[[Image:2y5t.jpg|left|200px]]
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==CRYSTAL STRUCTURE OF THE PATHOGENIC AUTOANTIBODY CIIC1 IN COMPLEX WITH THE TRIPLE-HELICAL C1 PEPTIDE==
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<StructureSection load='2y5t' size='340' side='right' caption='[[2y5t]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2y5t]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y5T OCA]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y5t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y5t RCSB], [http://www.ebi.ac.uk/pdbsum/2y5t PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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OBJECTIVE: In rheumatoid arthritis, joint inflammation and cartilage destruction are mediated by autoantibodies directed to various self antigens. Type II collagen (CII)-specific antibodies are likely to play a role in this process and have been shown to induce experimental arthritis in susceptible animals. The purpose of this study was to reveal how arthritogenic autoantibodies recognize native CII in its triple-helical conformation. METHODS: Site-directed mutagenesis and crystallographic studies were performed to reveal crucial contact points between the CII antibody and the triple-helical CII peptide. RESULTS: The crystal structure of a pathogenic autoantibody bound to a major triple-helical epitope present on CII was determined, allowing a first and detailed description of the interactions within an arthritogenic complex that is frequently occurring in both mice and humans with autoimmune arthritis. The crystal structure emphasizes the role of arginine residues located in a commonly recognized motif on CII and reveals that germline-encoded elements are involved in the interaction with the epitope. CONCLUSION: The crystal structure of an arthritogenic antibody binding a triple-helical epitope on CII indicates a crucial role of germline-encoded and arginine residues as the target structures.
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Crystal structure of an arthritogenic anticollagen immune complex.,Dobritzsch D, Lindh I, Uysal H, Nandakumar KS, Burkhardt H, Schneider G, Holmdahl R Arthritis Rheum. 2011 Dec;63(12):3740-8. doi: 10.1002/art.30611. PMID:22127694<ref>PMID:22127694</ref>
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The line below this paragraph, containing "STRUCTURE_2y5t", creates the "Structure Box" on the page.
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{{STRUCTURE_2y5t| PDB=2y5t | SCENE= }}
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===CRYSTAL STRUCTURE OF THE PATHOGENIC AUTOANTIBODY CIIC1 IN COMPLEX WITH THE TRIPLE-HELICAL C1 PEPTIDE===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22127694}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22127694 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22127694}}
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==About this Structure==
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[[2y5t]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y5T OCA].
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==Reference==
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<ref group="xtra">PMID:022127694</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Burkhardt, H.]]
[[Category: Burkhardt, H.]]

Revision as of 07:53, 14 May 2014

CRYSTAL STRUCTURE OF THE PATHOGENIC AUTOANTIBODY CIIC1 IN COMPLEX WITH THE TRIPLE-HELICAL C1 PEPTIDE

2y5t, resolution 2.20Å

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