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2xkx

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[[Image:2xkx.png|left|200px]]
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==Single particle analysis of PSD-95 in negative stain==
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<StructureSection load='2xkx' size='340' side='right' caption='[[2xkx]], [[Resolution|resolution]] 22.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2xkx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKX OCA]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1tq3|1tq3]], [[1rgr|1rgr]], [[1iu2|1iu2]], [[1jxm|1jxm]], [[1kjw|1kjw]], [[1tp3|1tp3]], [[1be9|1be9]], [[1bfe|1bfe]], [[1qlc|1qlc]], [[1iu0|1iu0]], [[1jxo|1jxo]], [[1tp5|1tp5]], [[2xky|2xky]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xkx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xkx RCSB], [http://www.ebi.ac.uk/pdbsum/2xkx PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The interaction of the extra-membranous domain of tetrameric inwardly rectifying Kir2.1 ion channels (Kir2.1NC(4)) with the membrane associated guanylate kinase protein PSD-95 has been studied using Transmission Electron Microscopy in negative stain. Three types of complexes were observed in electron micrographs corresponding to a 1:1 complex, a large self-enclosed tetrad complex and extended chains of linked channel domains. Using models derived from small angle X-ray scattering experiments in which high resolution structures from X-ray crystallographic and Nuclear Magnetic Resonance studies are positioned, the envelopes from single particle analysis can be resolved as a Kir2.1NC(4):PSD-95 complex and a tetrad of this unit (Kir2.1NC(4):PSD-95)(4). The tetrad complex shows the close association of the Kir2.1 cytoplasmic domains and the influence of PSD-95 mediated self-assembly on the clustering of these channels.
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Self-directed assembly and clustering of the cytoplasmic domains of inwardly rectifying Kir2.1 potassium channels on association with PSD-95.,Fomina S, Howard TD, Sleator OK, Golovanova M, O'Ryan L, Leyland ML, Grossmann JG, Collins RF, Prince SM Biochim Biophys Acta. 2011 Jul 5;1808(10):2374-2389. PMID:21756874<ref>PMID:21756874</ref>
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The line below this paragraph, containing "STRUCTURE_2xkx", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_2xkx| PDB=2xkx | SCENE= }}
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===SINGLE PARTICLE ANALYSIS OF PSD-95 IN NEGATIVE STAIN===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21756874}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21756874 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21756874}}
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==About this Structure==
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[[2xkx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XKX OCA].
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==Reference==
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<ref group="xtra">PMID:021756874</ref><ref group="xtra">PMID:012614619</ref><ref group="xtra">PMID:010623522</ref><ref group="xtra">PMID:011779504</ref><references group="xtra"/>
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Collins, R F.]]
[[Category: Collins, R F.]]

Revision as of 07:53, 14 May 2014

Single particle analysis of PSD-95 in negative stain

2xkx, resolution 22.90Å

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