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2xvr

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[[Image:2xvr.png|left|200px]]
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==Phage T7 empty mature head shell==
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<StructureSection load='2xvr' size='340' side='right' caption='[[2xvr]], [[Resolution|resolution]] 10.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2xvr]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Bpt7 Bpt7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVR OCA]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xvr RCSB], [http://www.ebi.ac.uk/pdbsum/2xvr PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Maturation of dsDNA bacteriophages involves assembling the virus prohead from a limited set of structural components, followed by rearrangements required for the stability that is necessary for infecting a host under challenging environmental conditions. Here, we determine the mature capsid structure of T7 at 1 nm resolution by cryo electron microscopy, and compare it with the prohead to reveal the molecular basis of T7 shell maturation. The mature capsid presents an expanded and thinner shell, with a drastic rearrangement of the major protein monomers that increases in their interacting surfaces, in turn resulting in a new bonding lattice. The rearrangements include tilting, in-plane rotation and radial expansion of the subunits, as well as a relative bending of the A and P-domains of each subunit. The unique features of this shell transformation, which does not employ the accessory proteins, inserted domains, or molecular interactions observed in other phages, suggest a simple capsid assembling strategy that may have appeared early in the evolution of these viruses.
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Molecular rearrangements involved in the capsid shell maturation of bacteriophage T7.,Ionel A, Velazquez-Muriel JA, Luque D, Cuervo A, Caston JR, Valpuesta JM, Martin-Benito J, Carrascosa JL J Biol Chem. 2010 Oct 20. PMID:20962334<ref>PMID:20962334</ref>
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The line below this paragraph, containing "STRUCTURE_2xvr", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_2xvr| PDB=2xvr | SCENE= }}
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===Phage T7 empty mature head shell===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_20962334}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 20962334 is the PubMed ID number.
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</StructureSection>
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[[Category: Bpt7]]
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{{ABSTRACT_PUBMED_20962334}}
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==About this Structure==
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[[2xvr]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t7 Enterobacteria phage t7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVR OCA].
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==Reference==
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<ref group="xtra">PMID:020962334</ref><references group="xtra"/>
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[[Category: Enterobacteria phage t7]]
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[[Category: Carrascosa, J L.]]
[[Category: Carrascosa, J L.]]
[[Category: Caston, J R.]]
[[Category: Caston, J R.]]

Revision as of 07:53, 14 May 2014

Phage T7 empty mature head shell

2xvr, resolution 10.80Å

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