Sandbox Reserved 931

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===Nucleic Acid Binding Surfaces===
===Nucleic Acid Binding Surfaces===
Here is an electrostatic map of the putative <scene name='57/579701/Orf1p_overall_structure/9'>nucleic acid binding surface</scene>.
Here is an electrostatic map of the putative <scene name='57/579701/Orf1p_overall_structure/9'>nucleic acid binding surface</scene>.
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==3D Structures of L1 ORF1 Protein===
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==Mus musculus (mouse)==
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Nuclear Magnetic Resonance: 2JRB,
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==Homo sapiens==
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X-Ray Crystallography: 2YKO, 2YKP, 2YKQ
==A Cool Movie==
==A Cool Movie==
["http://www.nature.com/nsmb/journal/v18/n9/extref/nsmb.2097-S2.mov"|Click]
["http://www.nature.com/nsmb/journal/v18/n9/extref/nsmb.2097-S2.mov"|Click]

Revision as of 10:18, 14 May 2014

This Sandbox is Reserved from 01/04/2014, through 30/06/2014 for use in the course "510042. Protein structure, function and folding" taught by Prof Adrian Goldman, Tommi Kajander, Taru Meri, Konstantin Kogan and Juho Kellosalo at the University of Helsinki. This reservation includes Sandbox Reserved 923 through Sandbox Reserved 947.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

LINE-1 ORF1 Protein

Long interspersed element 1 (LINE1) open reading frame 1 (L1ORF1) is a LINE-type retrotransposon (class I-transposon) in humans that is responsible for retrotransposition - a process increasing the DNA variety and size of the genome. The protein localizes to large L1 ribonucleoprotein particles, stress granules and nucleus (ref).

Introduction

During retrotransposition, the RNA transcript is reversely transcribed to DNA and integrated with the genome in different place than the original gene. The process is catalyzed by retrotransposons, which often integrate reverse transcriptase and endonuclease functions required in the process.

L1ORF1 localizes to ribonuclein particles, stress granules and nucleus. Although the protein has general affinity to nucleic acids, it displays a strong cis preference, what makes it bind primarily encoding RNA transcripts (ref). In a process known as target-primed reverse transcription, L1ORF1 reversely transcribes the mRNA at the point of genomic integration (ref) and assists with the integration with the DNA.

Structure

Something to replace later

Drag the structure with the mouse to rotate
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