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Sandbox Reserved 932
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===Structure=== | ===Structure=== | ||
| - | Denmotoxin is a monomeric protein possessing 77 amino acid residues including 10 structurally important cysteines. Multiple sequence alignment of denmotoxin reveals that the venom belongs to the family of non-conventional 3FTXs. Denmotoxins cysteines form <scene name='57/579702/Disulphides/2'>five disulphide bonds</scene> which stabilize the structure. Denmotoxin has 7 additional amino acid residues in its N-terminal when compared to other elapid 3FTXs; the N-terminus is also blocked by a pyroglutamic acid residue. There are two highly flexible regions on the protein: one at the tip of the central loop and one at the 3 first residues of the N-terminus. | + | Denmotoxin is a monomeric protein possessing 77 amino acid residues including 10 structurally important cysteines. Multiple sequence alignment of denmotoxin reveals that the venom belongs to the family of non-conventional 3FTXs. Denmotoxins cysteines form <scene name='57/579702/Disulphides/2'>five disulphide bonds</scene> which stabilize the structure. Denmotoxin has 7 additional amino acid residues in its N-terminal when compared to other elapid 3FTXs; the N-terminus is also blocked by a pyroglutamic acid residue. The cysteine residues of all 3FTXs are highly conserved, whereas the other residues within the sequence express high variabilty. The biological function of the pyroglutamic acid residue is currently unknown. There are two highly flexible regions on the protein: one at the tip of the central loop and one at the 3 first residues of the N-terminus. |
=== Denmotoxin interacts with acetylcholine-receptors === | === Denmotoxin interacts with acetylcholine-receptors === | ||
Revision as of 10:21, 14 May 2014
| This Sandbox is Reserved from 01/04/2014, through 30/06/2014 for use in the course "510042. Protein structure, function and folding" taught by Prof Adrian Goldman, Tommi Kajander, Taru Meri, Konstantin Kogan and Juho Kellosalo at the University of Helsinki. This reservation includes Sandbox Reserved 923 through Sandbox Reserved 947. |
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Denmotoxin
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