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Thioesterase

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Line 25: Line 25:
[[1q4t]] - ArTE + 4-hydroxyphenyl CoA<br />
[[1q4t]] - ArTE + 4-hydroxyphenyl CoA<br />
[[1q4u]] - ArTE + 4-hydroxybenzyl CoA<br />
[[1q4u]] - ArTE + 4-hydroxybenzyl CoA<br />
-
[[3r32]], [[3r35]], [[3r37]], [[3r38]], [[3r3c]], [[3r3d]], [[3r3f]], [[3tea]] - ArTE (mutant) + 4-hydroxyphenacyl CoA<br />
+
[[3r32]], [[3r35]], [[3r37]], [[3r38]], [[3r3b]], [[3r3c]], [[3r3d]], [[3r3f]], [[3tea]] - ArTE (mutant) + 4-hydroxyphenacyl CoA<br />
-
[[3r3a]] - ArTE (mutant) + 4-hydroxybenzoate<br />
+
[[3r36]] - ArTE (mutant) + 4-hydroxybenzoate<br />
 +
[[3r3a]] - ArTE (mutant) + 4-hydroxybenzoate + CoA<br />
[[3r34]] - ArTE (mutant) + CoA<br />
[[3r34]] - ArTE (mutant) + CoA<br />
Line 61: Line 62:
'''Acyl-ACP TE'''
'''Acyl-ACP TE'''
-
[[2ess]] – TE – ''Bacterioides thetaiotaomicron''
+
[[2ess]] – TE – ''Bacterioides thetaiotaomicron''<br />
 +
[[4gak]] – TE – ''Spirosoma linguale''<br />
 +
[[4gwh]] – TE – ''Yersinia pestis''<br />
 +
 
 +
'''ACP-polyene TE'''
 +
 
 +
[[4i4j]] – TE – ''Streptomyces globisporus''<br />
'''Fluoroacetyl-CoA TE'''
'''Fluoroacetyl-CoA TE'''
Line 69: Line 76:
[[3kvu]] – ScTE + acetyl-CoA<br />
[[3kvu]] – ScTE + acetyl-CoA<br />
[[3kvz]], [[3kw1]] – ScTE + FAcOPan<br />
[[3kvz]], [[3kw1]] – ScTE + FAcOPan<br />
-
[[3kx7]], [[3fx8]], [[3p2q]] – ScTE <br />
+
[[3kx7]], [[3kx8]], [[3p2q]] – ScTE <br />
[[3p3f]] – ScTE (mutant) <br />
[[3p3f]] – ScTE (mutant) <br />
[[3p3i]] - ScTE (mutant) + acetate derivative + CoA<br />
[[3p3i]] - ScTE (mutant) + acetate derivative + CoA<br />
 +
 +
'''DHNA-CoA TE'''
 +
 +
[[4k00]] – TE – ''Synechocystis''<br />
 +
[[4k02]] – TE – ''Arabidopsis thaliana''<br />
'''Ubiquitin TE'''
'''Ubiquitin TE'''
Line 167: Line 179:
[[3von]] – hUSP + E2 <BR />
[[3von]] – hUSP + E2 <BR />
[[4ddg]], [[4ddi]] – hUSP + Ub<BR />
[[4ddg]], [[4ddi]] – hUSP + Ub<BR />
-
[[4ddi]] – hUSP (mutant) + Ub<BR />
+
[[4ddi]], [[4i6l]] – hUSP (mutant) + Ub<BR />
[[4dhz]] – hUSP + E2 + Ub<BR />
[[4dhz]] – hUSP + E2 + Ub<BR />
 +
[[4boq]] - hUSP OTU domain <BR />
 +
[[4boz]] - hUSP OTU domain (mutant) + Ub <BR />
 +
[[4bos]] - hUSP OTU domain (mutant) + Ub + OTUD2 peptide<BR />
 +
[[4fjv]] - hUSP OTUB2 + Ub <BR />
[[4dhj]] – nUSP + E2 + Ub - nematode<BR />
[[4dhj]] – nUSP + E2 + Ub - nematode<BR />
[[4dhi]] – nUSP + E2 <BR />
[[4dhi]] – nUSP + E2 <BR />
 +
[[2kzr]] – mUSP UBX-like domain – NMR<br />
 +
[[4kdi]], [[4kdl]] – yUSP UBX-like domain + transitional endoplasmic reticulum ATPase<br />
 +
[[3by4]], [[3c0r]] - yUSP OTU domain + Ub<BR />
[[3znh]] – USP + Ub – Crimean-Congo hemorrhagic fever virus<BR />
[[3znh]] – USP + Ub – Crimean-Congo hemorrhagic fever virus<BR />
Line 178: Line 197:
[[3qmv]], [[3qmw]] – TE –'' Streptomyces coelicolor''
[[3qmv]], [[3qmw]] – TE –'' Streptomyces coelicolor''
 +
'''Orf6 TE'''
 +
 +
[[4i45]] – TE – ''Photobacterium profundum''<br />
-
[[2av9 ]]– TE – ''Pseudomonas aeruginosa''
+
[[2av9]], [[2o5u]], [[2o6b]], [[2o6t]], [[2o6u]], [[3qy3]] – TE – ''Pseudomonas aeruginosa''
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:16, 18 May 2014

Template:STRUCTURE 1u8u

Thioesterase (TE) catalyzes the break of an ester bond to produce acid and alcohol at a thiol group. TEs are substrate-specific. Palmitoyl protein TE removes fatty acids like palmitate from modified cysteine residues during lysosomal degradation. 4-hydroxybenzoyl-CoA TE converts 4-hydroxybenzoyl-CoA to 4-hydroxybenzoate and CoA. Acyl-CoA TE hydrolyzes acyl-CoA to the fatty acid and CoA and is involved in lipid metabolism. Fluoroacetyl-CoA TE from Streptomyces cattleya hydrolyzes fluoroacetyl-CoA thus preventing it from being metabolized to the lethal 4-hydroxy-trans-aconitate. Ubiquitin TE (USP) removes conjugated ubiquitin from proteins thus regulating protein level by preventing their degradation.

3D structures of thioesterase

Updated on 18-May-2014

Maristoyl-ACP-specific TE

1tht – TE – Vibrio harveyi

4-hydroxybenzoyl-CoA TE

1bvq – PsTE – Pseudomonas
1lo7 – PsTE + 4-hydroxyphenyl CoA
1lo9 - PsTE (mutant) + 4-hydroxybenzoyl CoA
1lo8 - PsTE + 4-hydroxybenzyl CoA
1q4s - ArTE + 4-hydroxybenzoate – 'Arthrobacter'
1q4t - ArTE + 4-hydroxyphenyl CoA
1q4u - ArTE + 4-hydroxybenzyl CoA
3r32, 3r35, 3r37, 3r38, 3r3b, 3r3c, 3r3d, 3r3f, 3tea - ArTE (mutant) + 4-hydroxyphenacyl CoA
3r36 - ArTE (mutant) + 4-hydroxybenzoate
3r3a - ArTE (mutant) + 4-hydroxybenzoate + CoA
3r34 - ArTE (mutant) + CoA

Palmitoyl protein TE

1eh5 – bTE1 + Palmitate – bovine
1ei9 – bTE1
1exw – bTE1 + hexadecylsulfonyl fluoride
1pja – hTEII – human
3gro - hTEI

Acyl-CoA TE

1c8u – EcTEII – Escherichia coli
1ivn – EcTEI
1jrl – EcTEI (mutant)
1j00 – EcTEI + diethyl phosphono derivative
1v2g, 1u8u - EcTEI + octanoic acid
2v1o – mTE7 hotdog domain – mouse
2q2b – mTE7 C terminal
3hlk – hTE2
3k2i – hTE4
2qq2 - hTE7 C terminal
3fo5 – hTE11 START domain
3b7k – hTE12
3rd7 – TE – Mycobacterium avium
3u0a – TEII – Mycobacterium marinum
1tbu – TE N terminal (peroximal) – yeast

Acyl protein TE

1fj2 – EcTEI

Acyl-ACP TE

2ess – TE – Bacterioides thetaiotaomicron
4gak – TE – Spirosoma linguale
4gwh – TE – Yersinia pestis

ACP-polyene TE

4i4j – TE – Streptomyces globisporus

Fluoroacetyl-CoA TE

3kuv, 3kuw, 3kvi – ScTE (mutant) + acetate derivative – Streptomyces cattleya
3kv7, 3kv8, 3p2r, 3p2s – ScTE + acetate derivative
3kvu – ScTE + acetyl-CoA
3kvz, 3kw1 – ScTE + FAcOPan
3kx7, 3kx8, 3p2q – ScTE
3p3f – ScTE (mutant)
3p3i - ScTE (mutant) + acetate derivative + CoA

DHNA-CoA TE

4k00 – TE – Synechocystis
4k02 – TE – Arabidopsis thaliana

Ubiquitin TE

USP 2

2zfy – hUSP – human
2hd5, 3nhe – hUSP + Ub
1tff – hUSP (mutant)
2ibi – hUSP (mutant) + Ub

USP 3

2qiy – USP + UBP-associated protein – yeast

USP 5

3ihp – hUSP + Ub

USP 7

2ylm, 2f1z – hUSP
2kvr – hUSP UBL domain - NMR
1nb8 – hUSP catalytic domain
1yze – hUSP N terminal domain
2f1w – hUSP TRAF-like domain
2f1x – hUSP TRAF-like domain + p53 peptide
2foj, 2foo – hUSP N terminal domain + p53 peptide
2f1y – hUSP TRAF-like domain + MDM2 peptide
2fop – hUSP N terminal domain + MDM2 peptide
1nbf – hUSP catalytic domain + ubiquitin aldehyde
1yy6 – hUSP N terminal domain + Epstein-Barr nuclear antigen
3mqr, 3mqs – hUSP + peptide
2xxn – hUSP + VIRF-4
4jjq – hUSP (mutant) + E2

USP 8

2a9u – hUSP N terminal domain
2gfo – hUSP catalytic domain
2gwf – hUSP rhodanese domain + ring finger protein
3mhh, 3m99, 4fip, 4fjc, 4fk5 – hUSP + SUS1 + SAGA-associated factors 11, 73
3mhs – hUSP + SUS1 + SAGA-associated factors 11, 73 + Ub
3n3k – hUSP + Ub inhibitor

USP 15

3lmn – hUSP DUSP domain

USP 16

2i50 – hUSP zinc finger domain - NMR

USP 21

3i3t – hUSP + Ub
3mtn – hUSP + Ub inhibitor

USP 28

2lva – hUSP N terminal - NMR

USP 33

2uzg – hUSP zinc finger domain - NMR

USP 37

3ihr – hUSP (mutant)
3a7s – hUSP catalytic domain (mutant)

USP Cyld

2vhf – hUSP

USP L1

3irt – hUSP (mutant)
2len – hUSP (mutant) - NMR
3ifw, 3kvf, 3kw5 – hUSP (mutant) + Ub
4dm9 – hUSP + peptide inhibitor

USP L5

3ris – hUSP catalytic domain
3rii – hUSP catalytic domain (mutant)
3tb3 – hUSP UCH domain (mutant)

USP ZranB1

3zrh – hUSP

USP OTUB1

3von – hUSP + E2
4ddg, 4ddi – hUSP + Ub
4ddi, 4i6l – hUSP (mutant) + Ub
4dhz – hUSP + E2 + Ub
4boq - hUSP OTU domain
4boz - hUSP OTU domain (mutant) + Ub
4bos - hUSP OTU domain (mutant) + Ub + OTUD2 peptide
4fjv - hUSP OTUB2 + Ub
4dhj – nUSP + E2 + Ub - nematode
4dhi – nUSP + E2
2kzr – mUSP UBX-like domain – NMR
4kdi, 4kdl – yUSP UBX-like domain + transitional endoplasmic reticulum ATPase
3by4, 3c0r - yUSP OTU domain + Ub

3znh – USP + Ub – Crimean-Congo hemorrhagic fever virus

RedJ TE

3qmv, 3qmw – TE – Streptomyces coelicolor

Orf6 TE

4i45 – TE – Photobacterium profundum

2av9, 2o5u, 2o6b, 2o6t, 2o6u, 3qy3 – TE – Pseudomonas aeruginosa

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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