3pub

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{{STRUCTURE_3pub| PDB=3pub | SCENE= }}
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==Crystal structure of the Bombyx mori low molecular weight lipoprotein 7 (Bmlp7)==
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===Crystal structure of the Bombyx mori low molecular weight lipoprotein 7 (Bmlp7)===
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<StructureSection load='3pub' size='340' side='right' caption='[[3pub]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
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{{ABSTRACT_PUBMED_21514389}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3pub]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bommo Bommo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PUB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PUB FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pub OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pub RCSB], [http://www.ebi.ac.uk/pdbsum/3pub PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The hemolymph of the fifth instar larvae of the silkworm Bombyx mori contains a group of homologous proteins with a molecular weight of approximately 30kDa, termed B. mori low molecular weight lipoproteins (Bmlps), which account for about 5% of the total plasma proteins. These so-called "30K proteins" have been reported to be involved in the innate immune response and transportation of lipid and/or sugar. To elucidate their molecular functions, we determined the crystal structure of a 30K protein, Bmlp7, at 1.91A. It has two distinct domains: an all-alpha N-terminal domain (NTD) and an all-beta C-terminal domain (CTD) of the beta-trefoil fold. Comparative structural analysis indicates that Bmlp7 represents a new family, adding to the 14 families currently identified, of the beta-trefoil superfamily. Structural comparison and simulation suggest that the NTD has a putative lipid-binding cavity, whereas the CTD has a potential sugar-binding site. However, we were unable to detect the binding of either lipid or sugar. Therefore, further investigations are needed to characterize the molecular function of this protein.
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==About this Structure==
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Crystal structure of the 30K protein from the silkworm Bombyx mori reveals a new member of the beta-trefoil superfamily.,Yang JP, Ma XX, He YX, Li WF, Kang Y, Bao R, Chen Y, Zhou CZ J Struct Biol. 2011 Jul;175(1):97-103. Epub 2011 Apr 14. PMID:21514389<ref>PMID:21514389</ref>
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[[3pub]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bombyx_mori Bombyx mori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PUB OCA].
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==Reference==
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:021514389</ref><references group="xtra"/><references/>
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</div>
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[[Category: Bombyx mori]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bommo]]
[[Category: Bao, R.]]
[[Category: Bao, R.]]
[[Category: Chen, Y.]]
[[Category: Chen, Y.]]

Revision as of 13:12, 18 May 2014

Crystal structure of the Bombyx mori low molecular weight lipoprotein 7 (Bmlp7)

3pub, resolution 1.91Å

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