1a58
From Proteopedia
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| - | [[Image:1a58.gif|left|200px]] | + | [[Image:1a58.gif|left|200px]] |
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| - | '''CYCLOPHILIN FROM BRUGIA MALAYI''' | + | {{Structure |
| + | |PDB= 1a58 |SIZE=350|CAPTION= <scene name='initialview01'>1a58</scene>, resolution 1.95Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= CYCLOPHILIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6279 Brugia malayi]) | ||
| + | }} | ||
| + | |||
| + | '''CYCLOPHILIN FROM BRUGIA MALAYI''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1A58 is a [ | + | 1A58 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Brugia_malayi Brugia malayi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A58 OCA]. |
==Reference== | ==Reference== | ||
| - | The X-ray structure of a divergent cyclophilin from the nematode parasite Brugia malayi., Taylor P, Page AP, Kontopidis G, Husi H, Walkinshaw MD, FEBS Lett. 1998 Mar 27;425(2):361-6. PMID:[http:// | + | The X-ray structure of a divergent cyclophilin from the nematode parasite Brugia malayi., Taylor P, Page AP, Kontopidis G, Husi H, Walkinshaw MD, FEBS Lett. 1998 Mar 27;425(2):361-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9559680 9559680] |
[[Category: Brugia malayi]] | [[Category: Brugia malayi]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: ppiase]] | [[Category: ppiase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:53:04 2008'' |
Revision as of 07:53, 20 March 2008
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| , resolution 1.95Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | CYCLOPHILIN (Brugia malayi) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CYCLOPHILIN FROM BRUGIA MALAYI
Overview
A structure of residues 1-177 of the cyclophilin domain of a large divergent cyclophilin from the filarial nematode parasite Brugia malayi has been crystallised and solved in two different crystal forms. The active site has a similar structure to that of human cyclophilin A. Two of the 13 residues important in forming the human cyclophilin A/cyclosporin A complex are altered in the B. malayi cyclophilin and explain the relatively poor inhibition of peptidyl prolyl isomerase activity by cyclosporin A.
About this Structure
1A58 is a Single protein structure of sequence from Brugia malayi. Full crystallographic information is available from OCA.
Reference
The X-ray structure of a divergent cyclophilin from the nematode parasite Brugia malayi., Taylor P, Page AP, Kontopidis G, Husi H, Walkinshaw MD, FEBS Lett. 1998 Mar 27;425(2):361-6. PMID:9559680
Page seeded by OCA on Thu Mar 20 09:53:04 2008
