4jm0

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{{STRUCTURE_4jm0| PDB=4jm0 | SCENE= }}
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==Structure of Human Cytomegalovirus Immune Modulator UL141==
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===Structure of Human Cytomegalovirus Immune Modulator UL141===
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<StructureSection load='4jm0' size='340' side='right' caption='[[4jm0]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[4jm0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hcmvm Hcmvm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JM0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JM0 FirstGlance]. <br>
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[[http://www.uniprot.org/uniprot/UL141_HCMVM UL141_HCMVM]] Evasion of NK cell killing. Blocks surface expression of PVR which is a ligand for NK cell-activating receptors. Binds human PVR in the endoplasmic reticulum and prevents its maturation and transport to the cell surface. Targets also the natural killer cell activating ligand PVRL2/Nectin-2 for proteasome-mediated degradation.<ref>PMID:20410314</ref>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4i9x|4i9x]]</td></tr>
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==About this Structure==
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jm0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jm0 RCSB], [http://www.ebi.ac.uk/pdbsum/4jm0 PDBsum]</span></td></tr>
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[[4jm0]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JM0 OCA].
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<table>
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__TOC__
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==Reference==
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</StructureSection>
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<references group="xtra"/><references/>
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[[Category: Hcmvm]]
[[Category: Nemcovicova, I.]]
[[Category: Nemcovicova, I.]]
[[Category: Zajonc, D M.]]
[[Category: Zajonc, D M.]]

Revision as of 13:30, 18 May 2014

Structure of Human Cytomegalovirus Immune Modulator UL141

4jm0, resolution 3.25Å

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