1a6a
From Proteopedia
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| - | [[Image:1a6a.gif|left|200px]] | + | [[Image:1a6a.gif|left|200px]] |
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| - | '''THE STRUCTURE OF AN INTERMEDIATE IN CLASS II MHC MATURATION: CLIP BOUND TO HLA-DR3''' | + | {{Structure |
| + | |PDB= 1a6a |SIZE=350|CAPTION= <scene name='initialview01'>1a6a</scene>, resolution 2.75Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''THE STRUCTURE OF AN INTERMEDIATE IN CLASS II MHC MATURATION: CLIP BOUND TO HLA-DR3''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1A6A is a [ | + | 1A6A is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A6A OCA]. |
==Reference== | ==Reference== | ||
| - | The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3., Ghosh P, Amaya M, Mellins E, Wiley DC, Nature. 1995 Nov 30;378(6556):457-62. PMID:[http:// | + | The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3., Ghosh P, Amaya M, Mellins E, Wiley DC, Nature. 1995 Nov 30;378(6556):457-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7477400 7477400] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: mhc glycoprotein]] | [[Category: mhc glycoprotein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:53:32 2008'' |
Revision as of 07:53, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
THE STRUCTURE OF AN INTERMEDIATE IN CLASS II MHC MATURATION: CLIP BOUND TO HLA-DR3
Overview
A complex between HLA-DR3 and a fragment of invariant chain called CLIP was isolated from a human cell line defective in antigen presentation and its X-ray crystal structure determined. Previous data indicate that this complex is an intermediate in class II histocompatibility maturation, occurring between invariant chain-DR3 and antigenic peptide-DR3 complexes. The structure shows that the CLIP fragment binds to DR3 in a way almost identical to that in which antigenic peptides bind class II histocompatibility glycoproteins. The structure is the substrate for the loading of antigenic peptides by an exchange process catalysed by DM.
About this Structure
1A6A is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3., Ghosh P, Amaya M, Mellins E, Wiley DC, Nature. 1995 Nov 30;378(6556):457-62. PMID:7477400
Page seeded by OCA on Thu Mar 20 09:53:32 2008
