1a6e

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[[Image:1a6e.gif|left|200px]]<br /><applet load="1a6e" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1a6e.gif|left|200px]]
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caption="1a6e, resolution 3.2&Aring;" />
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'''THERMOSOME-MG-ADP-ALF3 COMPLEX'''<br />
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{{Structure
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|PDB= 1a6e |SIZE=350|CAPTION= <scene name='initialview01'>1a6e</scene>, resolution 3.2&Aring;
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|SITE= <scene name='pdbsite=ASB:Residue+Numbering+According+To+Alpha-Type+Subunit'>ASB</scene> and <scene name='pdbsite=ASE:Residue+Numbering+According+To+Alpha-Type+Subunit'>ASE</scene>
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ADP:ADENOSINE-5'-DIPHOSPHATE'>ADP</scene> and <scene name='pdbligand=AF3:ALUMINUM FLUORIDE'>AF3</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''THERMOSOME-MG-ADP-ALF3 COMPLEX'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1A6E is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=ADP:'>ADP</scene> and <scene name='pdbligand=AF3:'>AF3</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=ASB:Residue+Numbering+According+To+Alpha-Type+Subunit'>ASB</scene> and <scene name='pdbsite=ASE:Residue+Numbering+According+To+Alpha-Type+Subunit'>ASE</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A6E OCA].
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1A6E is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A6E OCA].
==Reference==
==Reference==
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Crystal structure of the thermosome, the archaeal chaperonin and homolog of CCT., Ditzel L, Lowe J, Stock D, Stetter KO, Huber H, Huber R, Steinbacher S, Cell. 1998 Apr 3;93(1):125-38. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9546398 9546398]
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Crystal structure of the thermosome, the archaeal chaperonin and homolog of CCT., Ditzel L, Lowe J, Stock D, Stetter KO, Huber H, Huber R, Steinbacher S, Cell. 1998 Apr 3;93(1):125-38. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9546398 9546398]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Thermoplasma acidophilum]]
[[Category: Thermoplasma acidophilum]]
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[[Category: tric]]
[[Category: tric]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:41:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:53:35 2008''

Revision as of 07:53, 20 March 2008

Image:1a6e.gif


PDB ID 1a6e

Drag the structure with the mouse to rotate
, resolution 3.2Å
Sites: and
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



THERMOSOME-MG-ADP-ALF3 COMPLEX


Overview

We have determined to 2.6 A resolution the crystal structure of the thermosome, the archaeal group II chaperonin from T. acidophilum. The hexadecameric homolog of the eukaryotic chaperonin CCT/TRiC shows an (alphabeta)4(alphabeta)4 subunit assembly. Domain folds are homologous to GroEL but form a novel type of inter-ring contact. The domain arrangement resembles the GroEL-GroES cis-ring. Parts of the apical domains form a lid creating a closed conformation. The lid substitutes for a GroES-like cochaperonin that is absent in the CCT/TRiC system. The central cavity has a polar surface implicated in protein folding. Binding of the transition state analog Mg-ADP-AIF3 suggests that the closed conformation corresponds to the ATP form.

About this Structure

1A6E is a Protein complex structure of sequences from Thermoplasma acidophilum. Full crystallographic information is available from OCA.

Reference

Crystal structure of the thermosome, the archaeal chaperonin and homolog of CCT., Ditzel L, Lowe J, Stock D, Stetter KO, Huber H, Huber R, Steinbacher S, Cell. 1998 Apr 3;93(1):125-38. PMID:9546398

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