<table><tr><td colspan='2'>[[4p09]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P09 OCA]. <br>
+
<table><tr><td colspan='2'>[[4p09]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P09 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P09 FirstGlance]. <br>
-
</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
Linear ubiquitin chains are implicated in the regulation of the NF-kappaB pathway, immunity, and inflammation. They are synthesized by the LUBAC complex containing the catalytic subunit HOIL-1-interacting protein (HOIP) and are disassembled by the linear ubiquitin-specific deubiquitinase OTULIN. Little is known about the regulation of these opposing activities. Here we demonstrate that HOIP and OTULIN interact and act as a bimolecular editing pair for linear ubiquitin signals in vivo. The HOIP PUB domain binds to the PUB interacting motif (PIM) of OTULIN and the chaperone VCP/p97. Structural studies revealed the basis of high-affinity interaction with the OTULIN PIM. The conserved Tyr56 of OTULIN makes critical contacts with the HOIP PUB domain, and its phosphorylation negatively regulates this interaction. Functionally, HOIP binding to OTULIN is required for the recruitment of OTULIN to the TNF receptor complex and to counteract HOIP-dependent activation of the NF-kappaB pathway.
Binding of OTULIN to the PUB Domain of HOIP Controls NF-kappaB Signaling.,Schaeffer V, Akutsu M, Olma MH, Gomes LC, Kawasaki M, Dikic I Mol Cell. 2014 Apr 9. pii: S1097-2765(14)00221-4. doi:, 10.1016/j.molcel.2014.03.016. PMID:24726327[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
↑ Schaeffer V, Akutsu M, Olma MH, Gomes LC, Kawasaki M, Dikic I. Binding of OTULIN to the PUB Domain of HOIP Controls NF-kappaB Signaling. Mol Cell. 2014 Apr 9. pii: S1097-2765(14)00221-4. doi:, 10.1016/j.molcel.2014.03.016. PMID:24726327 doi:http://dx.doi.org/10.1016/j.molcel.2014.03.016
