1a8b

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[[Image:1a8b.gif|left|200px]]<br /><applet load="1a8b" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1a8b.gif|left|200px]]
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caption="1a8b, resolution 1.9&Aring;" />
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'''RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOETHANOLAMINE'''<br />
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{{Structure
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|PDB= 1a8b |SIZE=350|CAPTION= <scene name='initialview01'>1a8b</scene>, resolution 1.9&Aring;
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|SITE= <scene name='pdbsite=GPE:Gpe+Binding+Site+(Includes+1+Ca+Ion)'>GPE</scene>
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=GPE:L-ALPHA-GLYCEROPHOSPHORYLETHANOLAMINE'>GPE</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOETHANOLAMINE'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1A8B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=GPE:'>GPE</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Site: <scene name='pdbsite=GPE:Gpe+Binding+Site+(Includes+1+Ca+Ion)'>GPE</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8B OCA].
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1A8B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A8B OCA].
==Reference==
==Reference==
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Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V., Swairjo MA, Concha NO, Kaetzel MA, Dedman JR, Seaton BA, Nat Struct Biol. 1995 Nov;2(11):968-74. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7583670 7583670]
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Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V., Swairjo MA, Concha NO, Kaetzel MA, Dedman JR, Seaton BA, Nat Struct Biol. 1995 Nov;2(11):968-74. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7583670 7583670]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: phospholipid analog]]
[[Category: phospholipid analog]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:42:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:54:20 2008''

Revision as of 07:54, 20 March 2008

Image:1a8b.gif


PDB ID 1a8b

Drag the structure with the mouse to rotate
, resolution 1.9Å
Sites:
Ligands: and
Coordinates: save as pdb, mmCIF, xml



RAT ANNEXIN V COMPLEXED WITH GLYCEROPHOSPHOETHANOLAMINE


Overview

Structural evidence is presented for a 'Ca(2+)-bridging' mechanism, proposed for Ca(2+)-binding interfacial membrane proteins such as annexins, protein kinase C, and certain coagulation proteins. Crystal structures of Ca(2+)-annexin V complexes with phospholipid polar heads provide molecular details of 'Ca(2+)-bridges' as key features in the membrane attachment exhibited by these proteins. Distinct binding sites for phospholipid head groups are observed, including a novel, double-Ca2+ recognition site for phosphoserine that may serve as a phosphatidylserine receptor site in vivo.

About this Structure

1A8B is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin V., Swairjo MA, Concha NO, Kaetzel MA, Dedman JR, Seaton BA, Nat Struct Biol. 1995 Nov;2(11):968-74. PMID:7583670

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