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4cxa

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'''Unreleased structure'''
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==Crystal structure of the human CDK12-cyclin K complex bound to AMPPNP==
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<StructureSection load='4cxa' size='340' side='right' caption='[[4cxa]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
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The entry 4cxa is ON HOLD
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4cxa]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CXA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CXA FirstGlance]. <br>
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Authors: Dixon Clarke, S.E., Elkins, J.M., Pike, A.C.W., Nowak, R., Goubin, S., Mahajan, R.P., Kopec, J., Froese, S., Tallant, C., Carpenter, E.P., Mackenzie, A., Faust, B., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A.M., Bountra, C., Bullock, A.
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene><br>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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Description: Crystal structure of the human CDK12-cyclin K complex bound to AMPPNP
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cxa OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cxa RCSB], [http://www.ebi.ac.uk/pdbsum/4cxa PDBsum]</span></td></tr>
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<table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/CDK12_HUMAN CDK12_HUMAN]] Chromosomal aberrations involving CDK12 may be a cause gastric cancer. Deletions within 17q12 region producing fusion transcripts with ERBB2, leading to CDK12-ERBB2 fusion leading to trunctated CDK12 protein not in-frame with ERBB2.
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== Function ==
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[[http://www.uniprot.org/uniprot/CDK12_HUMAN CDK12_HUMAN]] Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogn inhibitors.<ref>PMID:11683387</ref> <ref>PMID:19651820</ref> <ref>PMID:20952539</ref> [[http://www.uniprot.org/uniprot/CCNK_HUMAN CCNK_HUMAN]] May play a role in transcriptional regulation. In vitro, is associated with a kinase activity toward both RNA polymerase II C-terminal domain and CDK2 (CAK).<ref>PMID:10574912</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Cyclin-dependent kinase]]
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[[Category: Arrowsmith, C.]]
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[[Category: Bountra, C.]]
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[[Category: Bullock, A.]]
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[[Category: Burgess-Brown, N.]]
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[[Category: Carpenter, E P.]]
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[[Category: Clarke, S E.Dixon.]]
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[[Category: Delft, F von.]]
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[[Category: Edwards, A M.]]
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[[Category: Elkins, J M.]]
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[[Category: Faust, B.]]
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[[Category: Froese, S.]]
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[[Category: Goubin, S.]]
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[[Category: Kopec, J.]]
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[[Category: Mackenzie, A.]]
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[[Category: Mahajan, R P.]]
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[[Category: Nowak, R.]]
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[[Category: Pike, A C.W.]]
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[[Category: Tallant, C.]]
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[[Category: Kinase]]
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[[Category: Transferase]]

Revision as of 09:15, 21 May 2014

Crystal structure of the human CDK12-cyclin K complex bound to AMPPNP

4cxa, resolution 3.15Å

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