1acy
From Proteopedia
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| - | [[Image:1acy.gif|left|200px]] | + | [[Image:1acy.gif|left|200px]] |
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| - | '''CRYSTAL STRUCTURE OF THE PRINCIPAL NEUTRALIZING SITE OF HIV-1''' | + | {{Structure |
| + | |PDB= 1acy |SIZE=350|CAPTION= <scene name='initialview01'>1acy</scene>, resolution 3.0Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''CRYSTAL STRUCTURE OF THE PRINCIPAL NEUTRALIZING SITE OF HIV-1''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1ACY is a [ | + | 1ACY is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(isolate_mn) Human immunodeficiency virus type 1 (isolate mn)] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ACY OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the principal neutralization site of HIV-1., Ghiara JB, Stura EA, Stanfield RL, Profy AT, Wilson IA, Science. 1994 Apr 1;264(5155):82-5. PMID:[http:// | + | Crystal structure of the principal neutralization site of HIV-1., Ghiara JB, Stura EA, Stanfield RL, Profy AT, Wilson IA, Science. 1994 Apr 1;264(5155):82-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7511253 7511253] |
[[Category: Human immunodeficiency virus type 1 (isolate mn)]] | [[Category: Human immunodeficiency virus type 1 (isolate mn)]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
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[[Category: complex(antibody/hiv-1 fragment)]] | [[Category: complex(antibody/hiv-1 fragment)]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:55:51 2008'' |
Revision as of 07:55, 20 March 2008
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| , resolution 3.0Å | |||||||
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF THE PRINCIPAL NEUTRALIZING SITE OF HIV-1
Overview
The crystal structure of a complex between a 24-amino acid peptide from the third variable (V3) loop of human immunodeficiency virus-type 1 (HIV-1) gp 120 and the Fab fragment of a broadly neutralizing antibody (59.1) was determined to 3 angstrom resolution. The tip of the V3 loop containing the Gly-Pro-Gly-Arg-Ala-Phe sequence adopts a double-turn conformation, which may be the basis of its conservation in many HIV-1 isolates. A complete map of the HIV-1 principal neutralizing determinant was constructed by stitching together structures of V3 loop peptides bound to 59.1 and to an isolate-specific (MN) neutralizing antibody (50.1). Structural conservation of the overlapping epitopes suggests that this biologically relevant conformation could be of use in the design of synthetic vaccines and drugs to inhibit HIV-1 entry and virus-related cellular fusion.
About this Structure
1ACY is a Protein complex structure of sequences from Human immunodeficiency virus type 1 (isolate mn) and Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structure of the principal neutralization site of HIV-1., Ghiara JB, Stura EA, Stanfield RL, Profy AT, Wilson IA, Science. 1994 Apr 1;264(5155):82-5. PMID:7511253
Page seeded by OCA on Thu Mar 20 09:55:51 2008
