3iyq

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[[Image:3iyq.png|left|200px]]
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==tmRNA-SmpB: a journey to the center of the bacterial ribosome==
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<StructureSection load='3iyq' size='340' side='right' caption='[[3iyq]], [[Resolution|resolution]] 13.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3iyq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IYQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IYQ FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3iyr|3iyr]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iyq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iyq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iyq RCSB], [http://www.ebi.ac.uk/pdbsum/3iyq PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Ribosomes mediate protein synthesis by decoding the information carried by messenger RNAs (mRNAs) and catalysing peptide bond formation between amino acids. When bacterial ribosomes stall on incomplete messages, the trans-translation quality control mechanism is activated by the transfer-messenger RNA bound to small protein B (tmRNA-SmpB ribonucleoprotein complex). Trans-translation liberates the stalled ribosomes and triggers degradation of the incomplete proteins. Here, we present the cryo-electron microscopy structures of tmRNA-SmpB accommodated or translocated into stalled ribosomes. Two atomic models for each state are proposed. This study reveals how tmRNA-SmpB crosses the ribosome and how, as the problematic mRNA is ejected, the tmRNA resume codon is placed onto the ribosomal decoding site by new contacts between SmpB and the nucleotides upstream of the tag-encoding sequence. This provides a structural basis for the transit of the large tmRNA-SmpB complex through the ribosome and for the means by which the tmRNA internal frame is set for translation to resume.
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tmRNA-SmpB: a journey to the centre of the bacterial ribosome.,Weis F, Bron P, Giudice E, Rolland JP, Thomas D, Felden B, Gillet R EMBO J. 2010 Nov 17;29(22):3810-8. Epub 2010 Oct 15. PMID:20953161<ref>PMID:20953161</ref>
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The line below this paragraph, containing "STRUCTURE_3iyq", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3iyq| PDB=3iyq | SCENE= }}
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===tmRNA-SmpB: a journey to the center of the bacterial ribosome===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_20953161}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 20953161 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_20953161}}
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==About this Structure==
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[[3iyq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IYQ OCA].
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==Reference==
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<ref group="xtra">PMID:020953161</ref><references group="xtra"/>
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[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
[[Category: Bron, P.]]
[[Category: Bron, P.]]

Revision as of 09:38, 21 May 2014

tmRNA-SmpB: a journey to the center of the bacterial ribosome

3iyq, resolution 13.00Å

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