3lim

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[[Image:3lim.png|left|200px]]
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==Crystal structure of the pore forming toxin frac from sea anemone actinia fragacea==
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<StructureSection load='3lim' size='340' side='right' caption='[[3lim]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3lim]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinia_fragacea Actinia fragacea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LIM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LIM FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene><br>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lim OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lim RCSB], [http://www.ebi.ac.uk/pdbsum/3lim PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Pore-forming toxins (PFTs) are proteins that are secreted as soluble molecules and are inserted into membranes to form oligomeric transmembrane pores. In this paper, we report the crystal structure of Fragaceatoxin C (FraC), a PFT isolated from the sea anemone Actinia fragacea, at 1.8 A resolution. It consists of a crown-shaped nonamer with an external diameter of about 11.0 nm and an internal diameter of approximately 5.0 nm. Cryoelectron microscopy studies of FraC in lipid bilayers reveal the pore structure that traverses the membrane. The shape and dimensions of the crystallographic oligomer are fully consistent with the membrane pore. The FraC structure provides insight into the interactions governing the assembly process and suggests the structural changes that allow for membrane insertion. We propose a nonameric pore model that spans the membrane by forming a lipid-free alpha-helical bundle pore.
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Structural insights into the oligomerization and architecture of eukaryotic membrane pore-forming toxins.,Mechaly AE, Bellomio A, Gil-Carton D, Morante K, Valle M, Gonzalez-Manas JM, Guerin DM Structure. 2011 Feb 9;19(2):181-91. PMID:21300287<ref>PMID:21300287</ref>
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The line below this paragraph, containing "STRUCTURE_3lim", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3lim| PDB=3lim | SCENE= }}
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===Crystal structure of the pore forming toxin frac from sea anemone actinia fragacea===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21300287}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21300287 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21300287}}
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==About this Structure==
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[[3lim]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinia_fragacea Actinia fragacea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LIM OCA].
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==Reference==
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<ref group="xtra">PMID:021300287</ref><references group="xtra"/>
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[[Category: Actinia fragacea]]
[[Category: Actinia fragacea]]
[[Category: Bellomio, A.]]
[[Category: Bellomio, A.]]

Revision as of 09:42, 21 May 2014

Crystal structure of the pore forming toxin frac from sea anemone actinia fragacea

3lim, resolution 1.80Å

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