1ae7
From Proteopedia
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| - | [[Image:1ae7.gif|left|200px]] | + | [[Image:1ae7.gif|left|200px]] |
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| - | '''NOTEXIN, A PRESYNAPTIC NEUROTOXIC PHOSPHOLIPASE A2''' | + | {{Structure |
| + | |PDB= 1ae7 |SIZE=350|CAPTION= <scene name='initialview01'>1ae7</scene>, resolution 2.0Å | ||
| + | |SITE= <scene name='pdbsite=CAL:Site+*Cal*+Comprises+Those+Residues+Forming+The+Ca2++Bin+...'>CAL</scene> and <scene name='pdbsite=CNR:Site+*Cnr*+Comprises+Those+Residues+Forming+The+Catalyti+...'>CNR</scene> | ||
| + | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''NOTEXIN, A PRESYNAPTIC NEUROTOXIC PHOSPHOLIPASE A2''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1AE7 is a [ | + | 1AE7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Notechis_scutatus_scutatus Notechis scutatus scutatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AE7 OCA]. |
==Reference== | ==Reference== | ||
| - | The three-dimensional structure of notexin, a presynaptic neurotoxic phospholipase A2 at 2.0 A resolution., Westerlund B, Nordlund P, Uhlin U, Eaker D, Eklund H, FEBS Lett. 1992 Apr 20;301(2):159-64. PMID:[http:// | + | The three-dimensional structure of notexin, a presynaptic neurotoxic phospholipase A2 at 2.0 A resolution., Westerlund B, Nordlund P, Uhlin U, Eaker D, Eklund H, FEBS Lett. 1992 Apr 20;301(2):159-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1568473 1568473] |
[[Category: Notechis scutatus scutatus]] | [[Category: Notechis scutatus scutatus]] | ||
[[Category: Phospholipase A(2)]] | [[Category: Phospholipase A(2)]] | ||
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[[Category: venom]] | [[Category: venom]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:56:17 2008'' |
Revision as of 07:56, 20 March 2008
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| , resolution 2.0Å | |||||||
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| Sites: | and | ||||||
| Ligands: | |||||||
| Activity: | Phospholipase A(2), with EC number 3.1.1.4 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
NOTEXIN, A PRESYNAPTIC NEUROTOXIC PHOSPHOLIPASE A2
Overview
The three-dimensional structure of notexin has been solved by molecular replacement methods. The structure has been refined at 2.0 A resolution to a crystallographic R-value of 16.5% with good stereo-chemistry. The core of the protein is very similar to other phospholipase A2s (PLA2 s) but several parts of the molecule are distinctly different. The most significant differences from PLA2 s from bovine pancreas and rattlesnake occur in the stretches 56-80 and 85-89. Residue 69, which has been shown to be important for phospholipase binding, has a different conformation and different interactions than in other known PLA2s. The C alpha positions for residues 86-88 differ by about 6 A from both the bovine and the rattlesnake enzyme. The crystals contain no Ca2+ ions. Instead, a water molecule occupies the calcium site.
About this Structure
1AE7 is a Single protein structure of sequence from Notechis scutatus scutatus. Full crystallographic information is available from OCA.
Reference
The three-dimensional structure of notexin, a presynaptic neurotoxic phospholipase A2 at 2.0 A resolution., Westerlund B, Nordlund P, Uhlin U, Eaker D, Eklund H, FEBS Lett. 1992 Apr 20;301(2):159-64. PMID:1568473
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