3ds7

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[[Image:3ds7.png|left|200px]]
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==Structure of an RNA-2'-deoxyguanosine complex==
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<StructureSection load='3ds7' size='340' side='right' caption='[[3ds7]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ds7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DS7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DS7 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GNG:2-DEOXY-GUANOSINE'>GNG</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene><br>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ds7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ds7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ds7 RCSB], [http://www.ebi.ac.uk/pdbsum/3ds7 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Riboswitches are noncoding RNA elements that are commonly found in the 5'-untranslated region of bacterial mRNA. Binding of a small-molecule metabolite to the riboswitch aptamer domain guides the folding of the downstream sequence into one of two mutually exclusive secondary structures that directs gene expression. The purine riboswitch family, which regulates aspects of purine biosynthesis and transport, contains three distinct classes that specifically recognize guanine/hypoxanthine, adenine, or 2'-deoxyguanosine (dG). Structural analysis of the guanine and adenine classes revealed a binding pocket that almost completely buries the nucleobase within the core of the folded RNA. Thus, it is somewhat surprising that this family of RNA elements also recognizes dG. We have used a combination of structural and biochemical techniques to understand how the guanine riboswitch could be converted into a dG binder and the structural basis for dG recognition. These studies reveal that a limited number of sequence changes to a guanine-sensing RNA are required to cause a specificity switch from guanine to 2'-deoxyguanosine, and to impart an altered structure for accommodating the additional deoxyribose sugar moiety.
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A structural basis for the recognition of 2'-deoxyguanosine by the purine riboswitch.,Edwards AL, Batey RT J Mol Biol. 2009 Jan 23;385(3):938-48. Epub 2008 Nov 5. PMID:19007790<ref>PMID:19007790</ref>
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The line below this paragraph, containing "STRUCTURE_3ds7", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3ds7| PDB=3ds7 | SCENE= }}
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===Structure of an RNA-2'-deoxyguanosine complex===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_19007790}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 19007790 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_19007790}}
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==About this Structure==
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[[3ds7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DS7 OCA].
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==Reference==
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<ref group="xtra">PMID:019007790</ref><references group="xtra"/>
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[[Category: Batey, R T.]]
[[Category: Batey, R T.]]
[[Category: Edwards, A L.]]
[[Category: Edwards, A L.]]

Revision as of 09:49, 21 May 2014

Structure of an RNA-2'-deoxyguanosine complex

3ds7, resolution 1.85Å

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OCA

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