3gom

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[[Image:3gom.png|left|200px]]
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==Barium bound to the Holliday junction sequence d(TCGGCGCCGA)4==
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<StructureSection load='3gom' size='340' side='right' caption='[[3gom]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3gom]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GOM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3GOM FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BA:BARIUM+ION'>BA</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1nvy|1nvy]], [[1p4y|1p4y]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gom OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gom RCSB], [http://www.ebi.ac.uk/pdbsum/3gom PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We describe a crystal structure, at atomic resolution (1.1 A, 100 K), of a ruthenium polypyridyl complex bound to duplex DNA, in which one ligand acts as a wedge in the minor groove, resulting in the 51 degrees kinking of the double helix. The complex cation Lambda-[Ru(1,4,5,8-tetraazaphenanthrene)(2)(dipyridophenazine)](2+) crystallizes in a 11 ratio with the oligonucleotide d(TCGGCGCCGA) in the presence of barium ions. Each complex binds to one duplex by intercalation of the dipyridophenazine ligand and also by semiintercalation of one of the orthogonal tetraazaphenanthrene ligands into a second symmetrically equivalent duplex. The result is noncovalent cross-linking and marked kinking of DNA.
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Structure determination of an intercalating ruthenium dipyridophenazine complex which kinks DNA by semiintercalation of a tetraazaphenanthrene ligand.,Hall JP, O'Sullivan K, Naseer A, Smith JA, Kelly JM, Cardin CJ Proc Natl Acad Sci U S A. 2011 Oct 3. PMID:21969542<ref>PMID:21969542</ref>
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The line below this paragraph, containing "STRUCTURE_3gom", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3gom| PDB=3gom | SCENE= }}
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===Barium bound to the Holliday junction sequence d(TCGGCGCCGA)4===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21969542}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21969542 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21969542}}
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==About this Structure==
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[[3gom]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GOM OCA].
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==Reference==
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<ref group="xtra">PMID:021969542</ref><references group="xtra"/>
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[[Category: Cardin, C J.]]
[[Category: Cardin, C J.]]
[[Category: Naseer, A.]]
[[Category: Naseer, A.]]
[[Category: Dna]]
[[Category: Dna]]
[[Category: Holliday junction structure]]
[[Category: Holliday junction structure]]

Revision as of 09:52, 21 May 2014

Barium bound to the Holliday junction sequence d(TCGGCGCCGA)4

3gom, resolution 2.30Å

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