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Transcriptional activator

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<StructureSection load='1h89' size='350' side='right' caption='Structure of transcriptional activator C-Myb DNA-binding domain (pink) complex with DNA, CAAT/enhancer binding protein β (grey and green) and K+ ion (purple) (PDB entry [[1h89]])' scene=''>
<StructureSection load='1h89' size='350' side='right' caption='Structure of transcriptional activator C-Myb DNA-binding domain (pink) complex with DNA, CAAT/enhancer binding protein β (grey and green) and K+ ion (purple) (PDB entry [[1h89]])' scene=''>
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'''Transcriptional activators''' (TA) are proteins which bind to DNA and stimulate nearby gene transcription. TA transcription stimulation is achieved by enhancing RNA polymerase binding or by enhancing the formation of open complex which is required for initiation of transcription. TA bind to a specific DNA sequence in or near an operon via their DNA-binding domain (DBD).
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'''Transcriptional activators''' (TA) are proteins which bind to DNA and stimulate nearby gene transcription. TA transcription stimulation is achieved by enhancing RNA polymerase binding or by enhancing the formation of open complex which is required for initiation of transcription. TA bind to a specific DNA sequence in or near an operon via their DNA-binding domain (DBD). TA contains 3 domains: DBD, trans-activating domain (TAD) which binds coregulator proteins and an optional ligand-binding domain (LBD) which sense external signals.
== 3D Structures of transcriptional activator==
== 3D Structures of transcriptional activator==
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See [[Gcn4]]
See [[Gcn4]]
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'''Gcn5 TA'''
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[[1e6i]] – yTA brododomain + histone H4 peptide - yeast<br />
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[[1ygh]] – yTA histone acetyltransferase domain <br />
'''C-Myb TA'''
'''C-Myb TA'''
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[[1gv5]] – mTA DBD repeat 2 <br />
[[1gv5]] – mTA DBD repeat 2 <br />
[[1gvd]] – mTA DBD repeat 2 (mutant) <br />
[[1gvd]] – mTA DBD repeat 2 (mutant) <br />
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[[1sb0]], [[2agh]] – mTA transcription activation domain + CREB-binding protein - NMR<br />
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[[1idy]], [[1idz]] – mTA DBD repeat 3 (mutant) - NMR<br />
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[[1sb0]], [[2agh]] – mTA TAD + CREB-binding protein - NMR<br />
'''Psp operon TA'''
'''Psp operon TA'''
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[[1tyh]], [[1yaf]] – BsTA – ''Bacillus subtilis''<br />
[[1tyh]], [[1yaf]] – BsTA – ''Bacillus subtilis''<br />
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[[2qzc]] – TA – ''Sulfolobus solfataricus''<br />
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[[3no6]] – TA – ''Staphylococcus epidermidis''<br />
[[1yak]] – BsTA + pyrimidine derivative<br />
[[1yak]] – BsTA + pyrimidine derivative<br />
[[2qcx]] – BsTA (mutant) + pyrimidine derivative<br />
[[2qcx]] – BsTA (mutant) + pyrimidine derivative<br />
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'''LasR TA'''
'''LasR TA'''
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[[2uv0]] – PaTA ligand-binding domain – ''Pseudomonas aeruginosa''<br />
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[[2uv0]] – PaTA LBD – ''Pseudomonas aeruginosa''<br />
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[[3ix3]] – PaTA ligand-binding domain + oxo-dodecanoyl-homoserine lactone<br />
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[[3ix3]] – PaTA LBD + oxo-dodecanoyl-homoserine lactone<br />
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[[3ix4]], [[3ix8]], [[3jpu]] – PaTA ligand-binding domain + benzoate derivative<br />
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[[3ix4]], [[3ix8]], [[3jpu]] – PaTA LBD + benzoate derivative<br />
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[[4ng2]] – PaTA LBD + protein<br />
'''CadC TA'''
'''CadC TA'''
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'''CynR TA'''
'''CynR TA'''
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[[2hxr]] – EcTA ligand-binding domain <br />
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[[2hxr]] – EcTA LBD <br />
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[[3hfu]] – EcTA ligand-binding domain + N3<br />
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[[3hfu]] – EcTA LBD + N3<br />
'''Mal-Rpel TA'''
'''Mal-Rpel TA'''
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[[1l3l]] – AtTA + pheromone + DNA – ''Agrobacterium tumefaciens'' <br />
[[1l3l]] – AtTA + pheromone + DNA – ''Agrobacterium tumefaciens'' <br />
[[1h0m]] – AtTA + auto-inducer + DNA <br />
[[1h0m]] – AtTA + auto-inducer + DNA <br />
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'''Flagelar TA'''
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[[1g8e]] – EcTA FLHD<br />
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[[2avu]] – EcTA FLHC+FLHD<br />
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'''TipA TA'''
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[[1ny9]] – SlTA antibiotic binding domain – ''Streptomyces lividans'' - NMR<br />
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[[2vz4]] – SlTA DBD + DNA<br />
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'''MtaN TA'''
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[[1r8d]] – BsTA <br />
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'''RfaH TA'''
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[[2oug]] – EcTA <br />
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[[2lcl]] – EcTA C terminal - NMR<br />
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'''SoxR TA'''
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[[2zhh]] – EcTA <br />
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[[2zhg]] – EcTA + DNA<br />
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'''AmpR TA'''
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[[3kos]] – CfTA effector binding domain – ''Citrobacter freundii''<br />
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[[3kot]] – CfTA effector binding domain (mutant)<br />
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'''GlxR TA'''
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[[3r6s]] – TA +cAMP – ''Corynebacterium glutamicum'' <br />
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'''OxyR TA'''
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[[3t22]] – TA regulatory domain – ''Porphyromonas gingivalis'' <br />
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'''PlcR TA'''
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[[4fsc]] – BtTA - ''Bacillus thuringiensis'' <br />
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[[3u3w]] – BtTA + DNA + PAPR peptide <br />
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'''VirB TA'''
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[[3vwb]], [[3w2a]], [[3w3c]] – TA core domain + DNA – ''Shigella flexneri''<br />
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'''MafA TA'''
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[[4eot]] – hTA DBD<br />
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'''CysB TA'''
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[[4gwo]], [[4gxa]] – TA C terminal – ''Salmonella typhimurium''<br />
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'''HlyU TA'''
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[[4k2e]] – TA - ''Vibrio cholerae''<br />
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'''Aft2 TA'''
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[[4lmg]] – yTA + DNA<br />
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[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:38, 22 May 2014

Structure of transcriptional activator C-Myb DNA-binding domain (pink) complex with DNA, CAAT/enhancer binding protein β (grey and green) and K+ ion (purple) (PDB entry 1h89)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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