Tumor necrosis factor

Tumor necrosis factor (TNF) is a cytokine which can cause apoptosis. TNFα is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNF alpha converting enzyme (TACE or ADAM17 see A Disintegrin And Metalloproteinase).

3D Structures of tumor necrosis factor

Updated on 26-May-2014

TNF alpha

1tnf – hTNF – human
2tun, 1a8m, 4tsv, 5tsw, 2e7e, 2zjc, 2zpx – hTNF (mutant)
2tnf – TNF – mouse
2az5 – hTNF + inhibitor
3it8 – hTNF + poxvirus 2L protein
3l9j – hTNF + antagonist
3alq – hTNF (mutant) + TNF receptor
4g3y, 3wd5 – hTNF + antibody

TNF beta

1tnr – hTNF + TNF receptor p55

TNF

2vfj – hTNF ovarian tumor domain