4p9r
From Proteopedia
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| - | ''' | + | ==Speciation of a group I intron into a lariat capping ribozyme (Heavy atom derivative)== |
| + | <StructureSection load='4p9r' size='340' side='right' caption='[[4p9r]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4p9r]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P9R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P9R FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IRI:IRIDIUM+HEXAMMINE+ION'>IRI</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br> | ||
| + | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4p8z|4p8z]], [[4p95|4p95]]</td></tr> | ||
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p9r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p9r RCSB], [http://www.ebi.ac.uk/pdbsum/4p9r PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The lariat-capping (LC) ribozyme is a natural ribozyme isolated from eukaryotic microorganisms. Despite apparent structural similarity to group I introns, the LC ribozyme catalyzes cleavage by a 2',5' branching reaction, leaving the 3' product with a 3-nt lariat cap that functionally substitutes for a conventional mRNA cap in the downstream pre-mRNA encoding a homing endonuclease. We describe the crystal structures of the precleavage and postcleavage LC ribozymes, which suggest that structural features inherited from group I ribozymes have undergone speciation due to profound changes in molecular selection pressure, ultimately giving rise to an original branching ribozyme family. The structures elucidate the role of key elements that regulate the activity of the LC ribozyme by conformational switching and suggest a mechanism by which the signal for branching is transmitted to the catalytic core. The structures also show how conserved interactions twist residues, forming the lariat to join chemical groups involved in branching. | ||
| - | + | Speciation of a group I intron into a lariat capping ribozyme.,Meyer M, Nielsen H, Olieric V, Roblin P, Johansen SD, Westhof E, Masquida B Proc Natl Acad Sci U S A. 2014 May 12. PMID:24821772<ref>PMID:24821772</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Johansen, S D.]] | ||
| + | [[Category: Masquida, B.]] | ||
| + | [[Category: Meyer, M.]] | ||
| + | [[Category: Nielsen, H.]] | ||
| + | [[Category: Olieric, V.]] | ||
| + | [[Category: Roblin, P.]] | ||
| + | [[Category: Westhof, E.]] | ||
| + | [[Category: Branching reaction]] | ||
| + | [[Category: Catalytic rna]] | ||
| + | [[Category: Lariat fold]] | ||
| + | [[Category: Lariat-capping ribozyme]] | ||
| + | [[Category: Rna]] | ||
Revision as of 09:48, 28 May 2014
Speciation of a group I intron into a lariat capping ribozyme (Heavy atom derivative)
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