1ajj

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[[Image:1ajj.gif|left|200px]]<br /><applet load="1ajj" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1ajj.gif|left|200px]]
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caption="1ajj, resolution 1.7&Aring;" />
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'''LDL RECEPTOR LIGAND-BINDING MODULE 5, CALCIUM-COORDINATING'''<br />
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{{Structure
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|PDB= 1ajj |SIZE=350|CAPTION= <scene name='initialview01'>1ajj</scene>, resolution 1.7&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=CA:CALCIUM ION'>CA</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''LDL RECEPTOR LIGAND-BINDING MODULE 5, CALCIUM-COORDINATING'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1AJJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AJJ OCA].
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1AJJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AJJ OCA].
==Reference==
==Reference==
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Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module., Fass D, Blacklow S, Kim PS, Berger JM, Nature. 1997 Aug 14;388(6643):691-3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9262405 9262405]
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Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module., Fass D, Blacklow S, Kim PS, Berger JM, Nature. 1997 Aug 14;388(6643):691-3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9262405 9262405]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: receptor]]
[[Category: receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:45:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:58:25 2008''

Revision as of 07:58, 20 March 2008

Image:1ajj.gif


PDB ID 1ajj

Drag the structure with the mouse to rotate
, resolution 1.7Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



LDL RECEPTOR LIGAND-BINDING MODULE 5, CALCIUM-COORDINATING


Contents

Overview

The low-density lipoprotein receptor (LDLR) is responsible for the uptake of cholesterol-containing lipoprotein particles into cells. The amino-terminal region of LDLR, which consists of seven tandemly repeated, approximately 40-amino-acid, cysteine-rich modules (LDL-A modules), mediates binding to lipoproteins. LDL-A modules are biologically ubiquitous domains, found in over 100 proteins in the sequence database. The structure of ligand-binding repeat 5 (LR5) of the LDLR, determined to 1.7 A resolution by X-ray crystallography and presented here, contains a calcium ion coordinated by acidic residues that lie at the carboxy-terminal end of the domain and are conserved among LDL-A modules. Naturally occurring point mutations found in patients with the disease familial hypercholesterolaemia alter residues that directly coordinate Ca2+ or that serve as scaffolding residues of LR5.

Disease

Known disease associated with this structure: Hypercholesterolemia, familial OMIM:[606945]

About this Structure

1AJJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module., Fass D, Blacklow S, Kim PS, Berger JM, Nature. 1997 Aug 14;388(6643):691-3. PMID:9262405

Page seeded by OCA on Thu Mar 20 09:58:25 2008

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