3oqt

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[[Image:3oqt.png|left|200px]]
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==Crystal structure of Rv1498A protein from mycobacterium tuberculosis==
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<StructureSection load='3oqt' size='340' side='right' caption='[[3oqt]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3oqt]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OQT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OQT FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT1547, Rv1498.1, Rv1498A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oqt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3oqt RCSB], [http://www.ebi.ac.uk/pdbsum/3oqt PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Dodecins (assembly of twelve monomers) are the smallest known flavoprotein with only 65-73 amino acids and are involved in binding and storage of flavins in archaea. Here we report the crystal structure of Rv1498A, a Mycobacterium tuberculosis dodecin. This bacterial dodecin structure is similar to that of other reported dodecins. Each monomer has a 3 stranded beta-sheet and an alpha-helix perpendicular to it. This protein has polyextreme (halophilic and thermophilic) properties. Interestingly, positively and negatively charged residues aggregate separately and do not seem to contribute to thermophilic and halophilic stability. We have examined the interactions that stabilize the Rv1498A dodecamer by preparing selected point mutants that break salt bridges and hydrophobic contacts, thereby leading to collapse of the assembly.
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Structural and biophysical characterization of Mycobacterium tuberculosis dodecin Rv1498A.,Liu F, Xiong J, Kumar S, Yang C, Ge S, Li S, Xia N, Swaminathan K J Struct Biol. 2011 Jul;175(1):31-8. Epub 2011 Apr 24. PMID:21539921<ref>PMID:21539921</ref>
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The line below this paragraph, containing "STRUCTURE_3oqt", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3oqt| PDB=3oqt | SCENE= }}
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===Crystal structure of Rv1498A protein from mycobacterium tuberculosis===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21539921}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21539921 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21539921}}
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==About this Structure==
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[[3oqt]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OQT OCA].
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==Reference==
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<ref group="xtra">PMID:021539921</ref><references group="xtra"/>
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[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Ge, S.]]
[[Category: Ge, S.]]

Revision as of 10:28, 28 May 2014

Crystal structure of Rv1498A protein from mycobacterium tuberculosis

3oqt, resolution 2.88Å

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