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3nx5

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[[Image:3nx5.png|left|200px]]
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==The crystal structure of Sanguinarine bound to DNA d(CGTACG)==
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<StructureSection load='3nx5' size='340' side='right' caption='[[3nx5]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3nx5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NX5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NX5 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SAU:13-METHYL[1,3]BENZODIOXOLO[5,6-C][1,3]DIOXOLO[4,5-I]PHENANTHRIDIN-13-IUM'>SAU</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3np6|3np6]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nx5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nx5 RCSB], [http://www.ebi.ac.uk/pdbsum/3nx5 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The first crystal structures of Berberine and Sanguinarine intercalated with a d(CGTACG)(2) DNA sequence were obtained by X-ray diffraction analysis at 2.3 A resolution. Both drugs join the end of two "two-molecules" DNA units, stacked in a non-classic intercalation site formed by six bases. Sanguinarine interacts with d(CGTACG)(2) DNA in its iminium form.
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<!--
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X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d(CGTACG).,Ferraroni M, Bazzicalupi C, Bilia AR, Gratteri P Chem Commun (Camb). 2011 May 7;47(17):4917-9. Epub 2011 Mar 22. PMID:21431128<ref>PMID:21431128</ref>
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The line below this paragraph, containing "STRUCTURE_3nx5", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3nx5| PDB=3nx5 | SCENE= }}
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===The crystal structure of Sanguinarine bound to DNA d(CGTACG)===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21431128}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21431128 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21431128}}
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==About this Structure==
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[[3nx5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NX5 OCA].
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==Reference==
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<ref group="xtra">PMID:021431128</ref><references group="xtra"/>
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[[Category: Bazzicalupi, C.]]
[[Category: Bazzicalupi, C.]]
[[Category: Bilia, A R.]]
[[Category: Bilia, A R.]]

Revision as of 10:43, 28 May 2014

The crystal structure of Sanguinarine bound to DNA d(CGTACG)

3nx5, resolution 2.31Å

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