1alu

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[[Image:1alu.gif|left|200px]]<br /><applet load="1alu" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1alu.gif|left|200px]]
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caption="1alu, resolution 1.9&Aring;" />
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'''HUMAN INTERLEUKIN-6'''<br />
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{{Structure
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|PDB= 1alu |SIZE=350|CAPTION= <scene name='initialview01'>1alu</scene>, resolution 1.9&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=TLA:L(+)-TARTARIC ACID'>TLA</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''HUMAN INTERLEUKIN-6'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1ALU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=TLA:'>TLA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ALU OCA].
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1ALU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ALU OCA].
==Reference==
==Reference==
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1.9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling., Somers W, Stahl M, Seehra JS, EMBO J. 1997 Mar 3;16(5):989-97. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9118960 9118960]
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1.9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling., Somers W, Stahl M, Seehra JS, EMBO J. 1997 Mar 3;16(5):989-97. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9118960 9118960]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: signaling]]
[[Category: signaling]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:45:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:59:18 2008''

Revision as of 07:59, 20 March 2008

Image:1alu.gif


PDB ID 1alu

Drag the structure with the mouse to rotate
, resolution 1.9Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



HUMAN INTERLEUKIN-6


Contents

Overview

Interleukin 6 (IL-6) has many biological activities in vivo, and deregulation has been implicated in many disease processes. IL-6, a 185 amino acid polypeptide was refolded, purified and crystallized. The crystals diffracted to beyond 1.9 A and the structure was solved using single isomorphous replacement. The X-ray structure of IL-6 is composed of a four helix bundle linked by loops and an additional mini-helix. 157 out of 185 residues are well defined in the final structure, with 18 N-terminal and 8 A-B loop amino acids displaying no interpretable electron density. The three-dimensional structure has been used to construct a model of IL-6 interacting with the IL-6 receptor (alpha-chain) and gp130 (beta-chain) that gives new insight into the process of molecular recognition and signaling. Based on this model, we predict a fourth binding site on IL-6, a low affinity IL-6-IL-6 interaction, which may be necessary for the sequential assembly of a functional hexameric IL-6 receptor complex.

Disease

Known diseases associated with this structure: Kaposi sarcoma, susceptibility to OMIM:[147620], Osteopenia/osteoporosis OMIM:[147620]

About this Structure

1ALU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

1.9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling., Somers W, Stahl M, Seehra JS, EMBO J. 1997 Mar 3;16(5):989-97. PMID:9118960

Page seeded by OCA on Thu Mar 20 09:59:18 2008

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