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User:John S. de Banzie/Globular Protein

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==Pending==
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==Simple Example of Globular Protein Structure==
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<StructureSection load='1ido' size='340' side='right' caption='Pending' scene='58/587846/Testrun/3'>
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<StructureSection load='1qvg' size='400' side='right' caption='U5 Spliceosomal protein, [[1qvg]]' scene='58/587846/Testrun/3'>
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This is a default text for your page '''John S. de Banzie/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
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Most proteins are globular proteins. This page uses the human spliceosomal protein U5-15kD to illustrate some basic features of globular proteins. Specifically:
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
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<scene name='58/587846/Testrun/3'>TextToBeDisplayed</scene>
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1. Globular proteins are compact and rarely have internal cavities.
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2. Globular protein structure is primarily stabilized by the hydrophobic interaction.
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3. Globular proteins have mixed secondary structure.
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== Function ==
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(U5-15kD is a component of the U5 small nuclear ribosomal protein particle (snRNP). This in turn is a component of the spliceosome, a macromolecule assembly involved in converting primary transcripts into functional mRNAs. U5-15kD was chosen for this page because it is small, but has the features necessary to illustrate the points being made.)
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== Disease ==
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The <scene name='58/587846/U5-15kd_sf/1'>space filling model</scene> of the protein shows that the protein is compact, globular, and has no signs of internal cavities.
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== Relevance ==
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<scene name='58/587846/U5-15kd_phobicity/1'>Colouring the hydrophilic and hydrophobic residues</scene> shows that the interior of the protein is primarily hydrophobic (red) and the exterior is primarily hydrophilic (blue).
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== Structural highlights ==
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The <scene name='58/587846/U5-15kd_ca/1'>cartoon view</scene> of the protein shows that the protein has mixed secondary structure. There are three segments of alpha-helix (magenta), six segments of beta-pleated sheet (gold), and some irregular regions (white).
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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</StructureSection>
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== References ==
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<references/>
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Revision as of 18:44, 31 May 2014

Simple Example of Globular Protein Structure

U5 Spliceosomal protein, 1qvg

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

John S. de Banzie

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