1ao7
From Proteopedia
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| - | [[Image:1ao7.gif|left|200px]] | + | [[Image:1ao7.gif|left|200px]] |
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| - | '''COMPLEX BETWEEN HUMAN T-CELL RECEPTOR, VIRAL PEPTIDE (TAX), AND HLA-A 0201''' | + | {{Structure |
| + | |PDB= 1ao7 |SIZE=350|CAPTION= <scene name='initialview01'>1ao7</scene>, resolution 2.6Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=EMC:ETHYL MERCURY ION'>EMC</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= HLA-A 0201 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), V BETA 12.3 [BV13S1] - D BETA 2.1 - J BETA 2.1 - ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), V ALPHA 2.3 [AV2S1A2] - J ALPHA 24 - C ALPHA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), V BETA 12.3 [BV13S1] - D BETA 2.1 - J BETA 2.1 - C BETA 2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
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| + | '''COMPLEX BETWEEN HUMAN T-CELL RECEPTOR, VIRAL PEPTIDE (TAX), AND HLA-A 0201''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1AO7 is a [ | + | 1AO7 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_t-lymphotropic_virus_1 Human t-lymphotropic virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AO7 OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of the complex between human T-cell receptor, viral peptide and HLA-A2., Garboczi DN, Ghosh P, Utz U, Fan QR, Biddison WE, Wiley DC, Nature. 1996 Nov 14;384(6605):134-41. PMID:[http:// | + | Structure of the complex between human T-cell receptor, viral peptide and HLA-A2., Garboczi DN, Ghosh P, Utz U, Fan QR, Biddison WE, Wiley DC, Nature. 1996 Nov 14;384(6605):134-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8906788 8906788] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Human t-lymphotropic virus 1]] | [[Category: Human t-lymphotropic virus 1]] | ||
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[[Category: viral peptide]] | [[Category: viral peptide]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:00:11 2008'' |
Revision as of 08:00, 20 March 2008
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| , resolution 2.6Å | |||||||
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| Ligands: | |||||||
| Gene: | HLA-A 0201 (Homo sapiens), V BETA 12.3 [BV13S1] - D BETA 2.1 - J BETA 2.1 - (Homo sapiens), V ALPHA 2.3 [AV2S1A2] - J ALPHA 24 - C ALPHA (Homo sapiens), V BETA 12.3 [BV13S1] - D BETA 2.1 - J BETA 2.1 - C BETA 2 (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
COMPLEX BETWEEN HUMAN T-CELL RECEPTOR, VIRAL PEPTIDE (TAX), AND HLA-A 0201
Contents |
Overview
Recognition by a T-cell antigen receptor (TCR) of peptide complexed with a major histocompatibility complex (MHC) molecule occurs through variable loops in the TCR structure which bury almost all the available peptide and a much larger area of the MHC molecule. The TCR fits diagonally across the MHC peptide-binding site in a surface feature common to all class I and class II MHC molecules, providing evidence that the nature of binding is general. A broadly applicable binding mode has implications for the mechanism of repertoire selection and the magnitude of alloreactions.
Disease
Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[142800], Ankylosing spondylitis, susceptibility to, 1 OMIM:[142800], Hypoproteinemia, hypercatabolic OMIM:[109700], Stevens-Johnson syndrome, susceptibility to OMIM:[142800]
About this Structure
1AO7 is a Protein complex structure of sequences from Homo sapiens and Human t-lymphotropic virus 1. Full crystallographic information is available from OCA.
Reference
Structure of the complex between human T-cell receptor, viral peptide and HLA-A2., Garboczi DN, Ghosh P, Utz U, Fan QR, Biddison WE, Wiley DC, Nature. 1996 Nov 14;384(6605):134-41. PMID:8906788
Page seeded by OCA on Thu Mar 20 10:00:11 2008
