1aoj
From Proteopedia
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| - | [[Image:1aoj.gif|left|200px]] | + | [[Image:1aoj.gif|left|200px]] |
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| - | '''THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER''' | + | {{Structure |
| + | |PDB= 1aoj |SIZE=350|CAPTION= <scene name='initialview01'>1aoj</scene>, resolution 2.5Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1AOJ is a [ | + | 1AOJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AOJ OCA]. |
==Reference== | ==Reference== | ||
| - | The SH3 domain of Eps8 exists as a novel intertwined dimer., Kishan KV, Scita G, Wong WT, Di Fiore PP, Newcomer ME, Nat Struct Biol. 1997 Sep;4(9):739-43. PMID:[http:// | + | The SH3 domain of Eps8 exists as a novel intertwined dimer., Kishan KV, Scita G, Wong WT, Di Fiore PP, Newcomer ME, Nat Struct Biol. 1997 Sep;4(9):739-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9303002 9303002] |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: signal transduction]] | [[Category: signal transduction]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:00:18 2008'' |
Revision as of 08:00, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER
Overview
SH3 domains are structurally well-characterized as monomeric modular units of protein structure that mediate protein-protein recognition in numerous signal transduction proteins. The X-ray crystallographic structure of the Eps8 SH3 domain reveals a novel variation of the canonical SH3 fold: the SH3 domain from Eps8 is a dimer formed by strand interchange. In addition, co-immunoprecipitation experiments show that intact Eps8 is multimeric in vivo. Hence, the SH3 domain of Eps8 may represent a dimerization motif.
About this Structure
1AOJ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
The SH3 domain of Eps8 exists as a novel intertwined dimer., Kishan KV, Scita G, Wong WT, Di Fiore PP, Newcomer ME, Nat Struct Biol. 1997 Sep;4(9):739-43. PMID:9303002
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