1aq1

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[[Image:1aq1.gif|left|200px]]<br /><applet load="1aq1" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1aq1.gif|left|200px]]
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caption="1aq1, resolution 2.0&Aring;" />
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'''HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE'''<br />
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{{Structure
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|PDB= 1aq1 |SIZE=350|CAPTION= <scene name='initialview01'>1aq1</scene>, resolution 2.0&Aring;
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|SITE= <scene name='pdbsite=STB:Staurosporine+Binding+Site'>STB</scene>
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|LIGAND= <scene name='pdbligand=STU:STAUROSPORINE'>STU</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Transferred_entry:_2.7.11.1 Transferred entry: 2.7.11.1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.37 2.7.1.37]
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|GENE=
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}}
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'''HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1AQ1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=STU:'>STU</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Transferred_entry:_2.7.11.1 Transferred entry: 2.7.11.1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.37 2.7.1.37] Known structural/functional Site: <scene name='pdbsite=STB:Staurosporine+Binding+Site'>STB</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQ1 OCA].
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1AQ1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AQ1 OCA].
==Reference==
==Reference==
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Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2., Lawrie AM, Noble ME, Tunnah P, Brown NR, Johnson LN, Endicott JA, Nat Struct Biol. 1997 Oct;4(10):796-801. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9334743 9334743]
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Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2., Lawrie AM, Noble ME, Tunnah P, Brown NR, Johnson LN, Endicott JA, Nat Struct Biol. 1997 Oct;4(10):796-801. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9334743 9334743]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: staurosporine]]
[[Category: staurosporine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:47:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:00:55 2008''

Revision as of 08:00, 20 March 2008

Image:1aq1.gif


PDB ID 1aq1

Drag the structure with the mouse to rotate
, resolution 2.0Å
Sites:
Ligands:
Activity: Transferred entry: 2.7.11.1, with EC number 2.7.1.37
Coordinates: save as pdb, mmCIF, xml



HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR STAUROSPORINE


Overview

Staurosporine exhibits nanomolar IC50 values against a wide range of protein kinases. The structure of a CDK2 staurosporine complex explains the tight binding of this inhibitor, and suggests features to be exploited in the design of specific inhibitors of CDKs.

About this Structure

1AQ1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2., Lawrie AM, Noble ME, Tunnah P, Brown NR, Johnson LN, Endicott JA, Nat Struct Biol. 1997 Oct;4(10):796-801. PMID:9334743

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