3pg0

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[[Image:3pg0.png|left|200px]]
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==Crystal structure of designed 3-fold symmetric protein, ThreeFoil==
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<StructureSection load='3pg0' size='340' side='right' caption='[[3pg0]], [[Resolution|resolution]] 1.62&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3pg0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PG0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PG0 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pg0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pg0 RCSB], [http://www.ebi.ac.uk/pdbsum/3pg0 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The high frequency of internal structural symmetry in common protein folds is presumed to reflect their evolutionary origins from the repetition and fusion of ancient peptide modules, but little is known about the primary sequence and physical determinants of this process. Unexpectedly, a sequence and structural analysis of symmetric subdomain modules within an abundant and ancient globular fold, the beta-trefoil, reveals that modular evolution is not simply a relic of the ancient past, but is an ongoing and recurring mechanism for regenerating symmetry, having occurred independently in numerous existing beta-trefoil proteins. We performed a computational reconstruction of a beta-trefoil subdomain module and repeated it to form a newly three-fold symmetric globular protein, ThreeFoil. In addition to its near perfect structural identity between symmetric modules, ThreeFoil is highly soluble, performs multivalent carbohydrate binding, and has remarkably high thermal stability. These findings have far-reaching implications for understanding the evolution and design of proteins via subdomain modules.
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Modular evolution and the origins of symmetry: reconstruction of a three-fold symmetric globular protein.,Broom A, Doxey AC, Lobsanov YD, Berthin LG, Rose DR, Howell PL, McConkey BJ, Meiering EM Structure. 2012 Jan 11;20(1):161-71. Epub 2011 Dec 15. PMID:22178248<ref>PMID:22178248</ref>
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The line below this paragraph, containing "STRUCTURE_3pg0", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3pg0| PDB=3pg0 | SCENE= }}
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===Crystal structure of designed 3-fold symmetric protein, ThreeFoil===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22178248}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22178248 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22178248}}
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==About this Structure==
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[[3pg0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PG0 OCA].
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==Reference==
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<ref group="xtra">PMID:022178248</ref><references group="xtra"/>
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[[Category: Synthetic construct]]
[[Category: Synthetic construct]]
[[Category: Broom, A.]]
[[Category: Broom, A.]]

Revision as of 05:30, 4 June 2014

Crystal structure of designed 3-fold symmetric protein, ThreeFoil

3pg0, resolution 1.62Å

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