3qle

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[[Image:3qle.png|left|200px]]
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==Structural Basis for the Function of Tim50 in the Mitochondrial Presequence Translocase==
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<StructureSection load='3qle' size='340' side='right' caption='[[3qle]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3qle]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_ec1118 Saccharomyces cerevisiae ec1118]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QLE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QLE FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EC1118_1P2_2410g ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=643680 Saccharomyces cerevisiae EC1118])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qle OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qle RCSB], [http://www.ebi.ac.uk/pdbsum/3qle PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Many mitochondrial proteins are synthesized as preproteins carrying amino-terminal presequences in the cytosol. The preproteins are imported by the translocase of the outer mitochondrial membrane and the presequence translocase of the inner membrane. Tim50 and Tim23 transfer preproteins through the intermembrane space to the inner membrane. We report the crystal structure of the intermembrane space domain of yeast Tim50 to 1.83 A resolution. A protruding beta-hairpin of Tim50 is crucial for interaction with Tim23, providing a molecular basis for the cooperation of Tim50 and Tim23 in preprotein translocation to the protein-conducting channel of the mitochondrial inner membrane.
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Structural Basis for the Function of Tim50 in the Mitochondrial Presequence Translocase.,Qian X, Gebert M, Hopker J, Yan M, Li J, Wiedemann N, van der Laan M, Pfanner N, Sha B J Mol Biol. 2011 Jun 17. PMID:21704637<ref>PMID:21704637</ref>
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The line below this paragraph, containing "STRUCTURE_3qle", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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{{STRUCTURE_3qle| PDB=3qle | SCENE= }}
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===Structural Basis for the Function of Tim50 in the Mitochondrial Presequence Translocase===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21704637}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21704637 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21704637}}
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==About this Structure==
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[[3qle]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_ec1118 Saccharomyces cerevisiae ec1118]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QLE OCA].
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==Reference==
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<ref group="xtra">PMID:021704637</ref><references group="xtra"/>
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[[Category: Saccharomyces cerevisiae ec1118]]
[[Category: Saccharomyces cerevisiae ec1118]]
[[Category: Gebert, M.]]
[[Category: Gebert, M.]]

Revision as of 05:31, 4 June 2014

Structural Basis for the Function of Tim50 in the Mitochondrial Presequence Translocase

3qle, resolution 1.83Å

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