3p8z

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3p8z" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:3p8z.png|left|200px]]
+
==Dengue Methyltransferase bound to a SAM-based inhibitor==
 +
<StructureSection load='3p8z' size='340' side='right' caption='[[3p8z]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3p8z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_3 Dengue virus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P8Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P8Z FirstGlance]. <br>
 +
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=36A:(S)-2-AMINO-4-(((2S,3S,4R,5R)-5-(6-(3-CHLOROBENZYLAMINO)-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHYLTHIO)BUTANOIC+ACID'>36A</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene><br>
 +
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3p97|3p97]]</td></tr>
 +
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p8z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p8z RCSB], [http://www.ebi.ac.uk/pdbsum/3p8z PDBsum]</span></td></tr>
 +
<table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Crystal structure analysis of Flavivirus methyltransferases uncovered a flavivirus-conserved cavity located next to the binding site for its cofactor, S-adenosyl-methionine (SAM). Chemical derivatization of S-adenosyl-homocysteine (SAH), the product inhibitor of the methylation reaction, with substituents that extend into the identified cavity, generated inhibitors that showed improved and selective activity against dengue virus methyltransferase (MTase), but not related human enzymes. Crystal structure of dengue virus MTase with a bound SAH derivative revealed that its N6-substituent bound in this cavity and induced conformation changes in residues lining the pocket. These findings demonstrate that one of the major hurdles for the development of methyltransferase-based therapeutics, namely selectivity for disease-related methyltransferases, can be overcome.
-
<!--
+
Small molecule inhibitors that selectively block dengue virus methyltransferase.,Lim SP, Sonntag LS, Noble C, Nilar SH, Ng RH, Zou G, Monaghan P, Chung KY, Dong H, Liu B, Bodenreider C, Lee G, Ding M, Chan WL, Wang G, Jian YL, Chao AT, Lescar J, Yin Z, Vedananda TR, Keller TH, Shi PY J Biol Chem. 2011 Feb 25;286(8):6233-40. Epub 2010 Dec 8. PMID:21147775<ref>PMID:21147775</ref>
-
The line below this paragraph, containing "STRUCTURE_3p8z", creates the "Structure Box" on the page.
+
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
-
or leave the SCENE parameter empty for the default display.
+
-
-->
+
-
{{STRUCTURE_3p8z| PDB=3p8z | SCENE= }}
+
-
===Dengue Methyltransferase bound to a SAM-based inhibitor===
+
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_21147775}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 21147775 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_21147775}}
+
-
 
+
-
==About this Structure==
+
-
[[3p8z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_3 Dengue virus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P8Z OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:021147775</ref><references group="xtra"/>
+
[[Category: Dengue virus 3]]
[[Category: Dengue virus 3]]
[[Category: Lescar, J.]]
[[Category: Lescar, J.]]

Revision as of 05:32, 4 June 2014

Dengue Methyltransferase bound to a SAM-based inhibitor

3p8z, resolution 1.70Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3p8z"
Views
Personal tools
Navigation
Toolbox