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3qd2

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[[Image:3qd2.png|left|200px]]
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==Crsytal structure of mouse PERK kinase domain==
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<StructureSection load='3qd2' size='340' side='right' caption='[[3qd2]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3qd2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QD2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QD2 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Eif2ak3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qd2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qd2 RCSB], [http://www.ebi.ac.uk/pdbsum/3qd2 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The endoplasmic reticulum (ER) unfolded protein response (UPR) is comprised of several intracellular signaling pathways that alleviate ER stress. The ER-localized transmembrane kinase PERK is one of three major ER stress transducers. Oligomerization of PERK's N-terminal ER luminal domain by ER stress promotes PERK trans-autophosphorylation of the C-terminal cytoplasmic kinase domain at multiple residues including Thr980 on the kinase activation loop. Activated PERK phosphorylates Ser51 of the alpha-subunit of translation initiation factor 2 (eIF2alpha), which inhibits initiation of protein synthesis and reduces the load of unfolded proteins entering the ER. The crystal structure of PERK's kinase domain has been determined to 2.8 A resolution. The structure resembles the back-to-back dimer observed in the related eIF2alpha kinase PKR. Phosphorylation of Thr980 stabilizes both the activation loop and helix alphaG in the C-terminal lobe, preparing the latter for eIF2alpha binding. The structure suggests conservation in the mode of activation of eIF2alpha kinases and is consistent with a `line-up' model for PERK activation triggered by oligomerization of its luminal domain.
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The structure of the PERK kinase domain suggests the mechanism for its activation.,Cui W, Li J, Ron D, Sha B Acta Crystallogr D Biol Crystallogr. 2011 May;67(Pt 5):423-8. Epub 2011 Apr 13. PMID:21543844<ref>PMID:21543844</ref>
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The line below this paragraph, containing "STRUCTURE_3qd2", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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{{STRUCTURE_3qd2| PDB=3qd2 | SCENE= }}
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===Crsytal structure of mouse PERK kinase domain===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21543844}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21543844 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21543844}}
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==About this Structure==
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[[3qd2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QD2 OCA].
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==Reference==
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<ref group="xtra">PMID:021543844</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]

Revision as of 05:33, 4 June 2014

Crsytal structure of mouse PERK kinase domain

3qd2, resolution 2.81Å

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