3pic

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[[Image:3pic.png|left|200px]]
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==Glucuronoyl Esterase catalytic domain (Cip2_GE) from Hypocrea jecorina==
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<StructureSection load='3pic' size='340' side='right' caption='[[3pic]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3pic]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Hypocrea_jecorina Hypocrea jecorina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PIC FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pic OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pic RCSB], [http://www.ebi.ac.uk/pdbsum/3pic PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of the catalytic domain of glucuronoyl esterase Cip2 from the fungus H. jecorina was determined at a resolution of 1.9 A. This is the first structure of the newly established carbohydrate esterase family 15. The structure has revealed the residues Ser278-His411-Glu301 present in a triad arrangement as the active site. Ser278 is present in the novel consensus sequence GCSRXG reported earlier in the members of CE-15 family. The active site is exposed on the surface of the protein which has implications for the ability of the enzyme to hydrolyze ester bonds of large substrates. Efforts are underway to obtain crystals of Cip2_GE complexed with inhibitor and synthetic substrates. The activity of the glucuronoyl esterase could play a significant role in plant biomass degradation as its expected role is to separate the lignin from hemicelluloses by hydrolysis of the ester bond between 4-O-methyl-D-glucuronic acid moieties of glucuronoxylans and aromatic alcohols of lignin.
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Structure of the catalytic domain of glucuronoyl esterase Cip2 from Hypocrea jecorina.,Pokkuluri PR, Duke NE, Wood SJ, Cotta MA, Li XL, Biely P, Schiffer M Proteins. 2011 Aug;79(8):2588-92. doi: 10.1002/prot.23088. Epub 2011 Jun 9. PMID:21661060<ref>PMID:21661060</ref>
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The line below this paragraph, containing "STRUCTURE_3pic", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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-->
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{{STRUCTURE_3pic| PDB=3pic | SCENE= }}
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===Glucuronoyl Esterase catalytic domain (Cip2_GE) from Hypocrea jecorina===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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==About this Structure==
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<references/>
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[[3pic]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Hypocrea_jecorina Hypocrea jecorina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PIC OCA].
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__TOC__
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:021661060</ref><references group="xtra"/>
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[[Category: Hypocrea jecorina]]
[[Category: Hypocrea jecorina]]
[[Category: Pokkuluri, P R.]]
[[Category: Pokkuluri, P R.]]

Revision as of 05:33, 4 June 2014

Glucuronoyl Esterase catalytic domain (Cip2_GE) from Hypocrea jecorina

3pic, resolution 1.90Å

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