1asx

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[[Image:1asx.gif|left|200px]]<br /><applet load="1asx" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1asx.gif|left|200px]]
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caption="1asx, resolution 2.8&Aring;" />
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'''APICAL DOMAIN OF THE CHAPERONIN FROM THERMOPLASMA ACIDOPHILUM'''<br />
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{{Structure
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|PDB= 1asx |SIZE=350|CAPTION= <scene name='initialview01'>1asx</scene>, resolution 2.8&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE ION'>PO4</scene>
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|ACTIVITY=
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|GENE= THSA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2303 Thermoplasma acidophilum])
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}}
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'''APICAL DOMAIN OF THE CHAPERONIN FROM THERMOPLASMA ACIDOPHILUM'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1ASX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum] with <scene name='pdbligand=PO4:'>PO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ASX OCA].
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1ASX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ASX OCA].
==Reference==
==Reference==
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Structure of the substrate binding domain of the thermosome, an archaeal group II chaperonin., Klumpp M, Baumeister W, Essen LO, Cell. 1997 Oct 17;91(2):263-70. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9346243 9346243]
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Structure of the substrate binding domain of the thermosome, an archaeal group II chaperonin., Klumpp M, Baumeister W, Essen LO, Cell. 1997 Oct 17;91(2):263-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9346243 9346243]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Thermoplasma acidophilum]]
[[Category: Thermoplasma acidophilum]]
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[[Category: thermosome]]
[[Category: thermosome]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:48:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:01:52 2008''

Revision as of 08:01, 20 March 2008

Image:1asx.gif


PDB ID 1asx

Drag the structure with the mouse to rotate
, resolution 2.8Å
Ligands:
Gene: THSA (Thermoplasma acidophilum)
Coordinates: save as pdb, mmCIF, xml



APICAL DOMAIN OF THE CHAPERONIN FROM THERMOPLASMA ACIDOPHILUM


Overview

The crystal structure of the substrate binding domain of the thermosome, the archaeal group II chaperonin, has been determined at 2.3 A resolution. The core resembles the apical domain of GroEL but lacks the hydrophobic residues implied in binding of substrates to group I chaperonins. Rather, a large hydrophobic surface patch is found in a novel helix-turn-helix motif, which is characteristic of all group II chaperonins including the eukaryotic TRiC/CCT complex. Models of the holochaperonin, which are consistent with cryo electron microscopy data, suggest a dual role of this helical protrusion in substrate binding and controlling access to the central cavity independent of a GroES-like cochaperonin.

About this Structure

1ASX is a Single protein structure of sequence from Thermoplasma acidophilum. Full crystallographic information is available from OCA.

Reference

Structure of the substrate binding domain of the thermosome, an archaeal group II chaperonin., Klumpp M, Baumeister W, Essen LO, Cell. 1997 Oct 17;91(2):263-70. PMID:9346243

Page seeded by OCA on Thu Mar 20 10:01:52 2008

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