1atk

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[[Image:1atk.gif|left|200px]]<br /><applet load="1atk" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1atk.gif|left|200px]]
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caption="1atk, resolution 2.20&Aring;" />
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'''CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH THE COVALENT INHIBITOR E-64'''<br />
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{{Structure
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|PDB= 1atk |SIZE=350|CAPTION= <scene name='initialview01'>1atk</scene>, resolution 2.20&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=E64:N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE'>E64</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38]
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|GENE=
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}}
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'''CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH THE COVALENT INHIBITOR E-64'''
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==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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1ATK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=E64:'>E64</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ATK OCA].
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1ATK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ATK OCA].
==Reference==
==Reference==
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Crystal structure of human osteoclast cathepsin K complex with E-64., Zhao B, Janson CA, Amegadzie BY, D'Alessio K, Griffin C, Hanning CR, Jones C, Kurdyla J, McQueney M, Qiu X, Smith WW, Abdel-Meguid SS, Nat Struct Biol. 1997 Feb;4(2):109-11. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9033588 9033588]
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Crystal structure of human osteoclast cathepsin K complex with E-64., Zhao B, Janson CA, Amegadzie BY, D'Alessio K, Griffin C, Hanning CR, Jones C, Kurdyla J, McQueney M, Qiu X, Smith WW, Abdel-Meguid SS, Nat Struct Biol. 1997 Feb;4(2):109-11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9033588 9033588]
[[Category: Cathepsin K]]
[[Category: Cathepsin K]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: sulfhydryl proteinase]]
[[Category: sulfhydryl proteinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:48:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:02:06 2008''

Revision as of 08:02, 20 March 2008

Image:1atk.gif


PDB ID 1atk

Drag the structure with the mouse to rotate
, resolution 2.20Å
Ligands:
Activity: Cathepsin K, with EC number 3.4.22.38
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH THE COVALENT INHIBITOR E-64


Disease

Known disease associated with this structure: Pycnodysostosis OMIM:[601105]

About this Structure

1ATK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human osteoclast cathepsin K complex with E-64., Zhao B, Janson CA, Amegadzie BY, D'Alessio K, Griffin C, Hanning CR, Jones C, Kurdyla J, McQueney M, Qiu X, Smith WW, Abdel-Meguid SS, Nat Struct Biol. 1997 Feb;4(2):109-11. PMID:9033588

Page seeded by OCA on Thu Mar 20 10:02:06 2008

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