3rtr

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[[Image:3rtr.png|left|200px]]
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==A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases==
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<StructureSection load='3rtr' size='340' side='right' caption='[[3rtr]], [[Resolution|resolution]] 3.21&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3rtr]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RTR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RTR FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CUL1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), RBX1, RNF75, ROC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rtr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rtr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rtr RCSB], [http://www.ebi.ac.uk/pdbsum/3rtr PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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How RING E3 ligases mediate E2-to-substrate ubiquitin-like protein (UBL) transfer remains unknown. Here we address how the RING E3 RBX1 positions NEDD8's E2 (UBC12) and substrate (CUL1). We find that existing structures are incompatible with CUL1 NEDD8ylation and report a new conformation of RBX1 that places UBC12 adjacent to CUL1. We propose RING domain rotation as a general mechanism for UBL transfer for the largest family of E3s.
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A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases.,Calabrese MF, Scott DC, Duda DM, Grace CR, Kurinov I, Kriwacki RW, Schulman BA Nat Struct Mol Biol. 2011 Jul 17;18(8):947-9. doi: 10.1038/nsmb.2086. PMID:21765416<ref>PMID:21765416</ref>
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The line below this paragraph, containing "STRUCTURE_3rtr", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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{{STRUCTURE_3rtr| PDB=3rtr | SCENE= }}
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===A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
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*[[Ubiquitin protein ligase|Ubiquitin protein ligase]]
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The line below this paragraph, {{ABSTRACT_PUBMED_21765416}}, adds the Publication Abstract to the page
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== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 21765416 is the PubMed ID number.
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<references/>
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__TOC__
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{{ABSTRACT_PUBMED_21765416}}
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</StructureSection>
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==About this Structure==
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[[3rtr]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RTR OCA].
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==Reference==
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<ref group="xtra">PMID:021765416</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Calabrese, M F.]]
[[Category: Calabrese, M F.]]

Revision as of 04:42, 5 June 2014

A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases

3rtr, resolution 3.21Å

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