3rdt

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[[Image:3rdt.png|left|200px]]
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==Crystal Structure of 809.B5 TCR complexed with MHC Class II I-Ab/3k peptide==
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<StructureSection load='3rdt' size='340' side='right' caption='[[3rdt]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3rdt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RDT FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3c60|3c60]], [[3c6l|3c6l]], [[3c5z|3c5z]], [[1lnu|1lnu]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H2-Aa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), H2-Ab1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rdt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rdt RCSB], [http://www.ebi.ac.uk/pdbsum/3rdt PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A limited set of T cell receptor (TCR) variable (V) gene segments are used to create a repertoire of TCRs that recognize all major histocompatibility complex (MHC) ligands within a species. How individual alphabetaTCRs are constructed to specifically recognize a limited set of MHC ligands is unclear. Here we have identified a role for the differential pairing of particular V gene segments in creating TCRs that recognized MHC class II ligands exclusively, or cross-reacted with classical and nonclassical MHC class I ligands. Biophysical and structural experiments indicated that TCR specificity for MHC ligands is not driven by germline-encoded pairwise interactions. Rather, identical TCRbeta chains can have altered peptide-MHC (pMHC) binding modes when paired with different TCRalpha chains. The ability of TCR chain pairing to modify how V region residues interact with pMHC helps to explain how the same V genes are used to create TCRs specific for unique MHC ligands.
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A Role for Differential Variable Gene Pairing in Creating T Cell Receptors Specific for Unique Major Histocompatibility Ligands.,Stadinski BD, Trenh P, Smith RL, Bautista B, Huseby PG, Li G, Stern LJ, Huseby ES Immunity. 2011 Nov 16. PMID:22101158<ref>PMID:22101158</ref>
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The line below this paragraph, containing "STRUCTURE_3rdt", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3rdt| PDB=3rdt | SCENE= }}
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===Crystal Structure of 809.B5 TCR complexed with MHC Class II I-Ab/3k peptide===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22101158}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22101158 is the PubMed ID number.
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</StructureSection>
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[[Category: Lk3 transgenic mice]]
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{{ABSTRACT_PUBMED_22101158}}
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==About this Structure==
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[[3rdt]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Mus_musculus,_synthetic_construct Mus musculus, synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RDT OCA].
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==Reference==
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<ref group="xtra">PMID:022101158</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Mus musculus, synthetic construct]]
 
[[Category: Huseby, E S.]]
[[Category: Huseby, E S.]]
[[Category: Stern, L J.]]
[[Category: Stern, L J.]]

Revision as of 04:43, 5 June 2014

Crystal Structure of 809.B5 TCR complexed with MHC Class II I-Ab/3k peptide

3rdt, resolution 2.70Å

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