3r1x

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[[Image:3r1x.png|left|200px]]
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==Crystal structure of 2-oxo-3-deoxygalactonate kinase from Klebsiella pneumoniae==
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<StructureSection load='3r1x' size='340' side='right' caption='[[3r1x]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3r1x]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae_subsp._pneumoniae Klebsiella pneumoniae subsp. pneumoniae]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3nuw 3nuw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R1X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3R1X FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dgoK, KPN78578_40560, KPN_04097 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=72407 Klebsiella pneumoniae subsp. pneumoniae])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-dehydro-3-deoxygalactonokinase 2-dehydro-3-deoxygalactonokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.58 2.7.1.58] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3r1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r1x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3r1x RCSB], [http://www.ebi.ac.uk/pdbsum/3r1x PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In most organisms, efficient D-galactose utilization requires the highly conserved Leloir pathway that converts D-galactose to D-glucose 1-phosphate. However, in some bacterial and fungal species alternative routes of D-galactose assimilation have been identified. In the so-called De Ley-Doudoroff pathway, D-galactose is metabolized into pyruvate and D-glyceraldehyde 3-phosphate in five consecutive reactions carried out by specific enzymes. The penultimate step in this pathway involves the phosphorylation of 2-oxo-3-deoxygalactonate to 2-oxo-3-deoxygalactonate 6-phosphate catalyzed by 2-oxo-3-deoxygalactonate kinase, with ATP serving as a phosphoryl-group donor. Here, a crystal structure of 2-oxo-3-deoxygalactonate kinase from Klebsiella pneumoniae determined at 2.1 A resolution is reported, the first structure of an enzyme from the De Ley-Doudoroff pathway. Structural comparison indicates that the enzyme belongs to the ASKHA (acetate and sugar kinases/hsc70/actin) family of phosphotransferases. The protein is composed of two alpha/beta domains, each of which contains a core common to all family members. Additional elements introduced between conserved structural motifs define the unique features of 2-oxo-3-deoxygalactonate kinase and possibly determine the biological function of the protein.
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Structure of 2-oxo-3-deoxygalactonate kinase from Klebsiella pneumoniae.,Michalska K, Cuff ME, Tesar C, Feldmann B, Joachimiak A Acta Crystallogr D Biol Crystallogr. 2011 Aug;67(Pt 8):678-89. Epub 2011, Jul 12. PMID:21795809<ref>PMID:21795809</ref>
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The line below this paragraph, containing "STRUCTURE_3r1x", creates the "Structure Box" on the page.
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{{STRUCTURE_3r1x| PDB=3r1x | SCENE= }}
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===Crystal structure of 2-oxo-3-deoxygalactonate kinase from Klebsiella pneumoniae===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21795809}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21795809 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21795809}}
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==About this Structure==
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[[3r1x]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae_subsp._pneumoniae Klebsiella pneumoniae subsp. pneumoniae]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3nuw 3nuw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R1X OCA].
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==Reference==
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<ref group="xtra">PMID:021795809</ref><references group="xtra"/>
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[[Category: 2-dehydro-3-deoxygalactonokinase]]
[[Category: 2-dehydro-3-deoxygalactonokinase]]
[[Category: Klebsiella pneumoniae subsp. pneumoniae]]
[[Category: Klebsiella pneumoniae subsp. pneumoniae]]

Revision as of 04:51, 5 June 2014

Crystal structure of 2-oxo-3-deoxygalactonate kinase from Klebsiella pneumoniae

3r1x, resolution 2.09Å

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