3rx5
From Proteopedia
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| - | [[ | + | ==structure of AaCel9A in complex with cellotriose-like isofagomine== |
| + | <StructureSection load='3rx5' size='340' side='right' caption='[[3rx5]], [[Resolution|resolution]] 1.99Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3rx5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius_subsp._acidocaldarius Alicyclobacillus acidocaldarius subsp. acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RX5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RX5 FirstGlance]. <br> | ||
| + | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CBI:CELLOBIOSE'>CBI</scene>, <scene name='pdbligand=G2I:(3R,4R,5R)-3-HYDROXY-5-(HYDROXYMETHYL)PIPERIDIN-4-YL+4-O-BETA-D-GLUCOPYRANOSYL-BETA-D-GLUCOPYRANOSIDE'>G2I</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br> | ||
| + | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3gzk|3gzk]], [[3h2w|3h2w]], [[3h3k|3h3k]], [[3rx7|3rx7]], [[3rx8|3rx8]]</td></tr> | ||
| + | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">celA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1388 Alicyclobacillus acidocaldarius subsp. acidocaldarius])</td></tr> | ||
| + | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulase Cellulase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.4 3.2.1.4] </span></td></tr> | ||
| + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rx5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3rx5 RCSB], [http://www.ebi.ac.uk/pdbsum/3rx5 PDBsum]</span></td></tr> | ||
| + | <table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Using structural insight, the binding mode of isofagomine-derived inhibitors with family GH9 glycosidases is achieved via the study of Alicyclobacillus acidocaldarius (AaCel9A) endoglucanase. In contrast to what was observed in the first report using these compounds with inverting glycosidases from family GH6, these inhibitors do not adopt a distorted conformation in the active site. | ||
| - | + | A potential fortuitous binding of inhibitors of an inverting family GH9 beta-glycosidase derived from isofagomine.,Morera S, Vigouroux A, Stubbs KA Org Biomol Chem. 2011 Sep 7;9(17):5945-7. Epub 2011 Jul 25. PMID:21785782<ref>PMID:21785782</ref> | |
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| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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| - | == | + | |
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[[Category: Alicyclobacillus acidocaldarius subsp. acidocaldarius]] | [[Category: Alicyclobacillus acidocaldarius subsp. acidocaldarius]] | ||
[[Category: Cellulase]] | [[Category: Cellulase]] | ||
Revision as of 04:53, 5 June 2014
structure of AaCel9A in complex with cellotriose-like isofagomine
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