3skb

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[[Image:3skb.png|left|200px]]
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==Structural characterization of a GII.4 2004 norovirus variant (TCH05)==
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<StructureSection load='3skb' size='340' side='right' caption='[[3skb]], [[Resolution|resolution]] 3.22&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3skb]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SKB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SKB FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3sej|3sej]], [[3sjp|3sjp]], [[3sld|3sld]], [[3sln|3sln]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3skb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3skb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3skb RCSB], [http://www.ebi.ac.uk/pdbsum/3skb PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Susceptibility to norovirus (NoV), a major pathogen of epidemic gastroenteritis, is associated with histo-blood group antigens (HBGAs), which are also cell attachment factors for this virus. GII.4 NoV strains are predominantly associated with worldwide NoV epidemics with a periodic emergence of new variants. The sequence variations in the surface exposed P domain of the capsid protein resulting in differential HBGA binding patterns and antigenicity are suggested to drive GII.4 epochal evolution. To understand how temporal sequence variations affect the P domain structure and contribute to epochal evolution, we determined the P domain structure of a 2004 variant with ABH and secretor Lewis HBGAs and compared it with the previously determined structure of a 1996 variant. We show that temporal sequence variations do not affect the binding of monofucosyl ABH HBGAs but they can modulate the binding strength of difucosyl Lewis HBGAs and thus could contribute to epochal evolution by potentiated targeting of new variants to Lewis-positive secretor-positive individuals. The temporal variations also result in significant differences in the electrostatic landscape likely reflecting antigenic variations. The proximity of some of these changes to the HBGA binding sites suggests the possibility of a coordinated interplay between antigenicity and HBGA binding in epochal evolution. From the observation that the regions involved in the formation of the HBGA binding sites can be conformationally flexible, we suggest a plausible mechanism for how norovirus disassociates from salivary mucin-linked HBGA before re-associating with HBGAs linked to intestinal epithelial cells during its passage through the gastrointestinal tract.
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Structural Analysis of HBGA Binding Specificity in a Norovirus GII.4 Epidemic Variant: Implications for Epochal Evolution.,Shanker S, Choi JM, Sankaran B, Atmar RL, Estes MK, Prasad BV J Virol. 2011 Jun 29. PMID:21715503<ref>PMID:21715503</ref>
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The line below this paragraph, containing "STRUCTURE_3skb", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3skb| PDB=3skb | SCENE= }}
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===Structural characterization of a GII.4 2004 norovirus variant (TCH05)===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21715503}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21715503 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21715503}}
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==About this Structure==
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[[3skb]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SKB OCA].
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==Reference==
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<ref group="xtra">PMID:021715503</ref><references group="xtra"/>
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[[Category: Viruses]]
[[Category: Viruses]]
[[Category: Atmar, R L.]]
[[Category: Atmar, R L.]]

Revision as of 05:17, 5 June 2014

Structural characterization of a GII.4 2004 norovirus variant (TCH05)

3skb, resolution 3.22Å

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