1axn
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1axn.gif|left|200px]] | + | [[Image:1axn.gif|left|200px]] |
| - | + | ||
| - | '''THE HIGH RESOLUTION STRUCTURE OF ANNEXIN III SHOWS DIFFERENCES WITH ANNEXIN V''' | + | {{Structure |
| + | |PDB= 1axn |SIZE=350|CAPTION= <scene name='initialview01'>1axn</scene>, resolution 1.78Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= HUMAN ANNEXIN III ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''THE HIGH RESOLUTION STRUCTURE OF ANNEXIN III SHOWS DIFFERENCES WITH ANNEXIN V''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1AXN is a [ | + | 1AXN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AXN OCA]. |
==Reference== | ==Reference== | ||
| - | The high-resolution crystal structure of human annexin III shows subtle differences with annexin V., Favier-Perron B, Lewit-Bentley A, Russo-Marie F, Biochemistry. 1996 Feb 13;35(6):1740-4. PMID:[http:// | + | The high-resolution crystal structure of human annexin III shows subtle differences with annexin V., Favier-Perron B, Lewit-Bentley A, Russo-Marie F, Biochemistry. 1996 Feb 13;35(6):1740-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8639653 8639653] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 19: | Line 28: | ||
[[Category: annexin family]] | [[Category: annexin family]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:03:32 2008'' |
Revision as of 08:03, 20 March 2008
| |||||||
| , resolution 1.78Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | HUMAN ANNEXIN III (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
THE HIGH RESOLUTION STRUCTURE OF ANNEXIN III SHOWS DIFFERENCES WITH ANNEXIN V
Overview
The structure of recombinant human annexin III was solved to 1.8 A resolution. Though homologous to annexin I and V, the annexin III structure shows significant differences. The tryptophan in the calcium loop of the third domain is exposed to the solvent, as in the structure of annexin V crystallized in high calcium concentrations, although the annexin III crystals were prepared at low calcium concentrations. The position of domain III relative to the other domains is different from both annexin V and I, suggesting further flexibility of the molecule. The entire N-terminus of the protein is well-defined in the present structure. The side chain of tryptophan 5 interacts with the hinge region of the hydrophillic channel, which could have an effect on the potential mobility of this region, as well as on its possible calcium channel behavior.
About this Structure
1AXN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The high-resolution crystal structure of human annexin III shows subtle differences with annexin V., Favier-Perron B, Lewit-Bentley A, Russo-Marie F, Biochemistry. 1996 Feb 13;35(6):1740-4. PMID:8639653
Page seeded by OCA on Thu Mar 20 10:03:32 2008
