3sdt

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[[Image:3sdt.png|left|200px]]
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==Structure of a three-domain sesquiterpene synthase: a prospective target for advanced biofuels production==
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<StructureSection load='3sdt' size='340' side='right' caption='[[3sdt]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3sdt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Abies_grandis Abies grandis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SDT FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AHD:4-AMINO-1-HYDROXYBUTANE-1,1-DIYLDIPHOSPHONATE'>AHD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3sae|3sae]], [[3sdq|3sdq]], [[3sdr|3sdr]], [[3sdu|3sdu]], [[3sdv|3sdv]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ag1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=46611 Abies grandis])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-bisabolene_synthase Alpha-bisabolene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.38 4.2.3.38] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sdt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sdt RCSB], [http://www.ebi.ac.uk/pdbsum/3sdt PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The sesquiterpene bisabolene was recently identified as a biosynthetic precursor to bisabolane, an advanced biofuel with physicochemical properties similar to those of D2 diesel. High-titer microbial bisabolene production was achieved using Abies grandis alpha-bisabolene synthase (AgBIS). Here, we report the structure of AgBIS, a three-domain plant sesquiterpene synthase, crystallized in its apo form and bound to five different inhibitors. Structural and biochemical characterization of the AgBIS terpene synthase Class I active site leads us to propose a catalytic mechanism for the cyclization of farnesyl diphosphate into bisabolene via a bisabolyl cation intermediate. Further, we describe the nonfunctional AgBIS Class II active site whose high similarity to bifunctional diterpene synthases makes it an important link in understanding terpene synthase evolution. Practically, the AgBIS crystal structure is important in future protein engineering efforts to increase the microbial production of bisabolene.
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Structure of a three-domain sesquiterpene synthase: a prospective target for advanced biofuels production.,McAndrew RP, Peralta-Yahya PP, DeGiovanni A, Pereira JH, Hadi MZ, Keasling JD, Adams PD Structure. 2011 Dec 7;19(12):1876-84. PMID:22153510<ref>PMID:22153510</ref>
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The line below this paragraph, containing "STRUCTURE_3sdt", creates the "Structure Box" on the page.
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{{STRUCTURE_3sdt| PDB=3sdt | SCENE= }}
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===Structure of a three-domain sesquiterpene synthase: a prospective target for advanced biofuels production===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22153510}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22153510 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22153510}}
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==About this Structure==
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[[3sdt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Abies_grandis Abies grandis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SDT OCA].
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==Reference==
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<ref group="xtra">PMID:022153510</ref><references group="xtra"/>
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[[Category: Abies grandis]]
[[Category: Abies grandis]]
[[Category: Alpha-bisabolene synthase]]
[[Category: Alpha-bisabolene synthase]]

Revision as of 05:26, 5 June 2014

Structure of a three-domain sesquiterpene synthase: a prospective target for advanced biofuels production

3sdt, resolution 1.89Å

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