1ay2

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[[Image:1ay2.gif|left|200px]]<br /><applet load="1ay2" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1ay2.gif|left|200px]]
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caption="1ay2, resolution 2.6&Aring;" />
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'''STRUCTURE OF THE FIBER-FORMING PROTEIN PILIN AT 2.6 ANGSTROMS RESOLUTION'''<br />
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{{Structure
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|PDB= 1ay2 |SIZE=350|CAPTION= <scene name='initialview01'>1ay2</scene>, resolution 2.6&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene> and <scene name='pdbligand=HTO:HEPTANE-1,2,3-TRIOL'>HTO</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''STRUCTURE OF THE FIBER-FORMING PROTEIN PILIN AT 2.6 ANGSTROMS RESOLUTION'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1AY2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae] with <scene name='pdbligand=PT:'>PT</scene> and <scene name='pdbligand=HTO:'>HTO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AY2 OCA].
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1AY2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AY2 OCA].
==Reference==
==Reference==
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Structure of the fibre-forming protein pilin at 2.6 A resolution., Parge HE, Forest KT, Hickey MJ, Christensen DA, Getzoff ED, Tainer JA, Nature. 1995 Nov 2;378(6552):32-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7477282 7477282]
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Structure of the fibre-forming protein pilin at 2.6 A resolution., Parge HE, Forest KT, Hickey MJ, Christensen DA, Getzoff ED, Tainer JA, Nature. 1995 Nov 2;378(6552):32-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7477282 7477282]
[[Category: Neisseria gonorrhoeae]]
[[Category: Neisseria gonorrhoeae]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: type 4 pilin]]
[[Category: type 4 pilin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:49:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:03:43 2008''

Revision as of 08:03, 20 March 2008

Image:1ay2.gif


PDB ID 1ay2

Drag the structure with the mouse to rotate
, resolution 2.6Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



STRUCTURE OF THE FIBER-FORMING PROTEIN PILIN AT 2.6 ANGSTROMS RESOLUTION


Overview

The crystallographic structure of Neisseria gonorrhoeae pilin, which assembles into the multifunctional pilus adhesion and virulence factor, reveals an alpha-beta roll fold with a striking 85 A alpha-helical spine and an O-linked disaccharide. Key residues stabilize interactions that allow sequence hypervariability, responsible for pilin's celebrated antigenic variation, within disulphide region beta-strands and connections. Pilin surface shape, hydrophobicity and sequence variation constrain pilus assembly to the packing of flat subunit faces against alpha 1 helices. Helical fibre assembly is postulated to form a core of coiled alpha 1 helices banded by beta-sheet, leaving carbohydrate and hypervariable sequence regions exposed to solvent.

About this Structure

1AY2 is a Single protein structure of sequence from Neisseria gonorrhoeae. Full crystallographic information is available from OCA.

Reference

Structure of the fibre-forming protein pilin at 2.6 A resolution., Parge HE, Forest KT, Hickey MJ, Christensen DA, Getzoff ED, Tainer JA, Nature. 1995 Nov 2;378(6552):32-8. PMID:7477282

Page seeded by OCA on Thu Mar 20 10:03:43 2008

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