3s63

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[[Image:3s63.jpg|left|200px]]
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==Saposin-like protein Na-SLP-1==
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<StructureSection load='3s63' size='340' side='right' caption='[[3s63]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3s63]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Necator_americanus Necator americanus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S63 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S63 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3s64|3s64]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s63 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s63 RCSB], [http://www.ebi.ac.uk/pdbsum/3s63 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Saposin-like proteins (SAPLIPs) from soil-transmitted helminths play pivotal roles in host-pathogen interactions and have a high potential as targets for vaccination against parasitic diseases. We have identified two non-orthologous SAPLIPs from human and dog hookworm, Na-SLP-1 and Ac-SLP-1, and solved their three-dimensional crystal structures. Both proteins share the property of membrane binding as monitored by liposome co-pelleting assays and monolayer adsorption. Neither SAPLIP displayed any significant haemolytic or bactericidal activity. Based on the structural information, as well as the results from monolayer adsorption, we propose models of membrane interactions for both SAPLIPs. Initial membrane contact of the monomeric Na-SLP-1 is most likely by electrostatic interactions between the membrane surface and a prominent basic surface patch. In case of the dimeric Ac-SLP-1, membrane interactions are most likely initiated by a unique tryptophan residue that has previously been implicated in membrane interactions in other SAPLIPs.
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Insights into the membrane interactions of the saposin-like proteins Na-SLP-1 and Ac-SLP-1 from human and dog hookworm.,Willis C, Wang CK, Osman A, Simon A, Pickering D, Mulvenna J, Riboldi-Tunicliffe A, Jones MK, Loukas A, Hofmann A PLoS One. 2011;6(10):e25369. Epub 2011 Oct 3. PMID:21991310<ref>PMID:21991310</ref>
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The line below this paragraph, containing "STRUCTURE_3s63", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3s63| PDB=3s63 | SCENE= }}
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===Saposin-like protein Na-SLP-1===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21991310}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21991310 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21991310}}
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==About this Structure==
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[[3s63]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Necator_americanus Necator americanus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S63 OCA].
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==Reference==
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<ref group="xtra">PMID:021991310</ref><references group="xtra"/>
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[[Category: Necator americanus]]
[[Category: Necator americanus]]
[[Category: Hofmann, A.]]
[[Category: Hofmann, A.]]

Revision as of 05:30, 5 June 2014

Saposin-like protein Na-SLP-1

3s63, resolution 2.70Å

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