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3v47

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[[Image:3v47.png|left|200px]]
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==Crystal structure of the N-tetminal fragment of zebrafish TLR5 in complex with Salmonella flagellin==
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<StructureSection load='3v47' size='340' side='right' caption='[[3v47]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3v47]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bdellostoma_burgeri Bdellostoma burgeri] and [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_dublin Salmonella enterica subsp. enterica serovar dublin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V47 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V47 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3v44|3v44]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fliC, fliC1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=98360 Salmonella enterica subsp. enterica serovar Dublin])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v47 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v47 RCSB], [http://www.ebi.ac.uk/pdbsum/3v47 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Toll-like receptor 5 (TLR5) binding to bacterial flagellin activates signaling through the transcription factor NF-kappaB and triggers an innate immune response to the invading pathogen. To elucidate the structural basis and mechanistic implications of TLR5-flagellin recognition, we determined the crystal structure of zebrafish TLR5 (as a variable lymphocyte receptor hybrid protein) in complex with the D1/D2/D3 fragment of Salmonella flagellin, FliC, at 2.47 angstrom resolution. TLR5 interacts primarily with the three helices of the FliC D1 domain using its lateral side. Two TLR5-FliC 1:1 heterodimers assemble into a 2:2 tail-to-tail signaling complex that is stabilized by quaternary contacts of the FliC D1 domain with the convex surface of the opposing TLR5. The proposed signaling mechanism is supported by structure-guided mutagenesis and deletion analyses on CBLB502, a therapeutic protein derived from FliC.
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Structural basis of TLR5-flagellin recognition and signaling.,Yoon SI, Kurnasov O, Natarajan V, Hong M, Gudkov AV, Osterman AL, Wilson IA Science. 2012 Feb 17;335(6070):859-64. PMID:22344444<ref>PMID:22344444</ref>
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The line below this paragraph, containing "STRUCTURE_3v47", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3v47| PDB=3v47 | SCENE= }}
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===Crystal structure of the N-tetminal fragment of zebrafish TLR5 in complex with Salmonella flagellin===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22344444}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22344444 is the PubMed ID number.
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</StructureSection>
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[[Category: Bdellostoma burgeri]]
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{{ABSTRACT_PUBMED_22344444}}
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==About this Structure==
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[[3v47]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Danio_rerio,_eptatretus_burgeri Danio rerio, eptatretus burgeri] and [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_dublin Salmonella enterica subsp. enterica serovar dublin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V47 OCA].
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==Reference==
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<ref group="xtra">PMID:022344444</ref><references group="xtra"/>
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[[Category: Danio rerio, eptatretus burgeri]]
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[[Category: Salmonella enterica subsp. enterica serovar dublin]]
[[Category: Salmonella enterica subsp. enterica serovar dublin]]
[[Category: Hong, H.]]
[[Category: Hong, H.]]

Revision as of 05:43, 5 June 2014

Crystal structure of the N-tetminal fragment of zebrafish TLR5 in complex with Salmonella flagellin

3v47, resolution 2.47Å

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