3ua8

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[[Image:3ua8.png|left|200px]]
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==Crystal Structure Analysis of a 6-Amino Quinazolinedione Sulfonamide bound to human GluR2==
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<StructureSection load='3ua8' size='340' side='right' caption='[[3ua8]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ua8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UA8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UA8 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=08W:N-METHYL-1-{3-[(METHYLSULFONYL)AMINO]-2,4-DIOXO-7-(TRIFLUOROMETHYL)-1,2,3,4-TETRAHYDROQUINAZOLIN-6-YL}-1H-IMIDAZOLE-4-CARBOXAMIDE'>08W</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3r7x|3r7x]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GRIA2, GLUR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ua8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ua8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ua8 RCSB], [http://www.ebi.ac.uk/pdbsum/3ua8 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A new set of quinazolinedione sulfonamide derivatives as competitive AMPA receptor antagonist with improved properties compared to 1 is disclosed. By modulating physico-chemical properties, compound 29 was identified with a low ED(50) of 5.5mg/kg in an animal model of anticonvulsant activity after oral dosage.
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6-Amino quinazolinedione sulfonamides as orally active competitive AMPA receptor antagonists.,Orain D, Ofner S, Koller M, Carcache DA, Froestl W, Allgeier H, Rasetti V, Nozulak J, Mattes H, Soldermann N, Floersheim P, Desrayaud S, Kallen J, Lingenhoehl K, Urwyler S Bioorg Med Chem Lett. 2011 Dec 8. PMID:22197388<ref>PMID:22197388</ref>
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The line below this paragraph, containing "STRUCTURE_3ua8", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3ua8| PDB=3ua8 | SCENE= }}
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===Crystal Structure Analysis of a 6-Amino Quinazolinedione Sulfonamide bound to human GluR2===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
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<!--
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*[[Ionotropic Glutamate Receptors|Ionotropic Glutamate Receptors]]
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The line below this paragraph, {{ABSTRACT_PUBMED_22197388}}, adds the Publication Abstract to the page
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== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 22197388 is the PubMed ID number.
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<references/>
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__TOC__
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{{ABSTRACT_PUBMED_22197388}}
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</StructureSection>
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==About this Structure==
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[[3ua8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UA8 OCA].
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==Reference==
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<ref group="xtra">PMID:022197388</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Kallen, J.]]
[[Category: Kallen, J.]]

Revision as of 05:44, 5 June 2014

Crystal Structure Analysis of a 6-Amino Quinazolinedione Sulfonamide bound to human GluR2

3ua8, resolution 1.90Å

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