3ugm

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[[Image:3ugm.png|left|200px]]
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==Structure of TAL effector PthXo1 bound to its DNA target==
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<StructureSection load='3ugm' size='340' side='right' caption='[[3ugm]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ugm]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Xanthomonas_oryzae Xanthomonas oryzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UGM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UGM FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pthXo1, PXO_00227 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=347 Xanthomonas oryzae])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ugm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ugm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ugm RCSB], [http://www.ebi.ac.uk/pdbsum/3ugm PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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DNA recognition by TAL effectors is mediated by tandem repeats, each 33 to 35 residues in length, that specify nucleotides via unique repeat variable diresidues (RVDs). The crystal structure of PthXo1 bound to its DNA target was determined using high-throughput computational structure prediction and validated by heavy-atom derivatization. Each repeat forms a left-handed, two-helix bundle that presents an RVD-containing loop to the DNA. The repeats self-associate to form a right-handed superhelix wrapped around the DNA major groove. The first RVD residue forms a stabilizing contact with the protein backbone, while the second makes a base-specific contact to the DNA sense strand. Two degenerate N-terminal repeats also interact with the DNA. Containing several RVDs and noncanonical associations, the structure illustrates the basis of TAL effector-DNA recognition.
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The Crystal Structure of TAL Effector PthXo1 Bound to Its DNA Target.,Mak AN, Bradley P, Cernadas RA, Bogdanove AJ, Stoddard BL Science. 2012 Jan 5. PMID:22223736<ref>PMID:22223736</ref>
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The line below this paragraph, containing "STRUCTURE_3ugm", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_3ugm| PDB=3ugm | SCENE= }}
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===Structure of TAL effector PthXo1 bound to its DNA target===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
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*[[TAL effector|TAL effector]]
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The line below this paragraph, {{ABSTRACT_PUBMED_22223736}}, adds the Publication Abstract to the page
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== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 22223736 is the PubMed ID number.
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<references/>
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__TOC__
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{{ABSTRACT_PUBMED_22223736}}
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</StructureSection>
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==About this Structure==
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[[3ugm]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Xanthomonas_oryzae Xanthomonas oryzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UGM OCA].
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==Reference==
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<ref group="xtra">PMID:022223736</ref><references group="xtra"/>
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[[Category: Xanthomonas oryzae]]
[[Category: Xanthomonas oryzae]]
[[Category: Bogdanove, A J.]]
[[Category: Bogdanove, A J.]]

Revision as of 05:48, 5 June 2014

Structure of TAL effector PthXo1 bound to its DNA target

3ugm, resolution 3.00Å

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